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2000〜2013
Top Page of Publication List
所属していた研究者名は下線で示しています The researchers, working in this lab, are
underlined
2013
1. Arai M, Ikawa Y, Chujo S, Hamaguchi Y, Ishida W, Shirasaki
F, Hasegawa M, Mukaida N, Fujimoto M, and Takehara K. Chemokine receptors CCR2 and CX3CR1 regulate
skin fibrosis in the mouse model of cytokine-induced systemic sclerosis.
J Dermatol Sci. 2013; 69 (3): 250-258. doi: 10.1016/j.jdermsci.2012.10.010.
(Abstract)
2. Liu H-X, Lopatina O, Higashida, Fujimoto H, Akther S, Inzhutova
A, Liang M, Zhong J, Tsuji T, Yoshihara T, Sumi K, Ishiyama M, Ma W-J,
Ozaki M, Yagitani S, Yokoyama, Mukaida N, Sakurai T, Hori O, Yoshioka K, Hirao A, Kato Y, Ishihara K, Kato I, Okamoto
H, Cherepanov SM, Salmina A, Hirai H, Asano M, Brown DA, Nagano I, and
Higashida H. Displays of mouse pup retrieval as paternal parental behaviour
following communicative interaction with maternal mates. Nature Commun
2013;4:1346. doi: 10.1038/ncomms2336.(Abstract)
3. Egawa M, Mukai K, Yoshikawa S, Iki M, Mukaida N, Kawano Y, Minegishi Y, and Karasuyama H. Inflammatory monocytes recruited to allergic skin acquire anti-inflammatory M2 phenotype via basophil-derived IL-4. Immunity 2013 Mar 21;38(3):570-80. doi:10.1016/j.immuni.2012.11.014. (Abstract)
4. Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R,, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, and Wada T. CCL2/CCR2 augments the
production of transforming growth factror-beta 1, type I collagen and CCL2
by human CD45/collagen I-positive cells under high glucose concentrations.
Clin Exp Nephrol 2013; 17 (6): 793-804 (Abstract)
5. Murakami Y, Watari K, Shibata T, Uba M, Ureshino H, Kawahara A, Abe
H, Izumi H, Mukaida N, Kuwano M, and Ono M. N-myc donwstream-regulated gene 1 promotes tumor
inflammatory angiogenesis through JNK activation and autocrine loop of
interleukin-1 alpha by human gastric cancer cells. J Biol Chem 2013; 288
(35): 25025-25037. doi: 10.1074/jbc/M113/472068 (Abstract)
6. Zhen F, Liu B, Wang Z, Yu X-J, Ni Q-X, Yang W-T, Mukaida N, and Li Y-Y. A novel regulatory mechanism of Pim-3 kinase stability and its involvement in pancreatic cancer progression. Mol Cancer Res 2013, 11 (12): 1508-1520. doi: 10.1158/1541-7786.MCR-13-0389 (Abstract)
7. Baba T, Naka K, Morishita S, Komatsu N, Hirao A, and Mukaida N. MIP-1alpha/CCL3-mediated maintenance of leukemia initiating cells in
the initiation process of chronic myeloid leukemia. J Exp Med 2013; 210
(12): 2881-2673. doi:10.1084/jem.20130112 (Abstract) (Free full-text)
8. Mukaida N, Sasaki S, and Baba T. Tumor immunotherapy by utilizing a double-edged sword, chemokines . In
Cancer Targetd Drug Delivery; and Elusive Dreams. (Bae YH, Mrsny RJ, and
Park K eds.) Springer Science + Business Media, New York, 2013: pp. 97-118.
(ISBN 978-1-4614-7875-1; doi 10.1007/978-1-4614-7876-8_4)
2012
1．Wang Y-Y, Taniguchi T, Baba T, Li Y-Y, Ishibashi H, and Mukaida N. Identification of a phenanthrene derivative as a potent anti-cancer drug with Pim kinase inhibitory activities. Cancer Sci 2012; 103 (1): 107-115. (Abstract)
2. Ishida Y, Kimura A, Inui M, Matsushima K, Mukaida N and Kondo T. Pivotal
role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor
cells in mouse wound healing. J Clin Invest 2012; 122 (2): 711-721. (Free full text)
3. Furuichi , Kokubo S, Hara A, Imamura R, Wang, Q, Kitajima S, Toyama
T. Okumura T, Matsushima K, Suda T, Mukaida N, Kaneko S, and Wada T. Fas ligand has a greater impact than TNF-alpha on apoptosis and inflammation in ischemic acute kidney injury. Nephron Extra 2012; 2: 27-38.
4. Marukawa Y, Nakamoto Y, Kakinoki K, Tsuchiyama T, Iida N, Kagaya T,
Sakai Y, Mukaida N and Kaneko S. Membrane-bound form of monocyte chemoattractant protein-1
enhances antitumor effects of suicide gene therapy in a model of hepatocellular
carcinoma. Cancer Gene Ther 2012; 19: 312-319. (Abstract)
5. Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto
K, Mukaida N, Nishioka Y, Sone S, and Nakagawa T, Uenaka T, and Yano S. Met kinase
inhihitor E7050 reverses three different mechanisms of hepatocyte growth
factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung
cancer. Clin Cancer Res 2012; 18 (6): 1663-1671. (Abstract) (Free full text)
6. Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura
T, Yamamoto H, Miyamoto K, Ginsberg HN, Mukaida N, Kaneko S, and Ota T. CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes 2012; 61 (7): 1680-1690. doi: 10.2337/db11-1506. (Free Full Text)
7. Lu P, Li L, Liu G, Baba T, Ishida Y, Nosaka M, Kondo T, Xhang X, and Mukaida N. Critical role of TNF-alpha-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization. Invest Ophthlmol Vis Sci 2012; 53 (7): 3516-3526. doi: 10.1167/iovs.10-5548. (Abstract)
8. Kimura A, Ishida, Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, and Kondo T. IFN-gamma is protective in cisplatin-induced renal injury
by enhancing autophagic flux. Kidney Int 2012 Nov; 82(10):1093-1104. doi: 10.1038/ki.2012.240.(Abstract)
9. Baba T, Badr MES, Tomaru U, Ishizu A, and Mukaida N. Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpalpha+ dendritic cells: murine model. PlosOne 2012 ; 7 (7): e41154.(Free Full Text)
10. Shang K, Bai Y-P, Wang C, Wang Z, Gu H-Y,Du X, Zhou X-Y, Zheng C-L,
Chi Y-Y, Mukaida N, and Li Y-Y. Crucial involvement of tumor-associated neutrophils
in the regulation of chronic colitis-associated carcinogenesis in mice.
PlosOne 2012; 7(12):e51848.(Free Full Text)
11. Mukaida N and Baba T. Chemokines in tumor development and progression. Exp Cell Res 2012; 318 (2): 95-102. (Invited review). (Abstract)
12. Fujii H, Baba T, Yamagishi M, Kuwano M, and Mukaida N. The role of a chemokine receptor, CCR2, in suppressing the development
of arthritis in IL-1 receptor antagonist-dericient mice. Inflammation Regeneration 2012; 32 (3): 124-131.
13. Mukaida N and Popivanova BK. Novel mediators for chronic inflammtation and oncogenic transformation:
tumor necrosis factor (TNF)-alpha. In From Inflammation to Cancer : Advances in Diagnosis and Therapy for Gastrointestinal
and Hepatological Diseases ( Cho CH and Yu J eds.) World Scientific Publishing
Co. Ltd., Singapore, 2012; pp. 259-276.
2011
1. Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K,
Fujita Y, Marukawa Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, and Kaneko S. Prolonged recurrence-free survival following OK432-stimuated dendritic cell transfer into patients with hepatocellular carcinoam during transcatheter hepatic arteiral embolization. Clin Exp Immunol 2011; 163 (2) 165-177 (Abstract).
2. Fujii H, Baba T, Ishida Y, Kondo T, Yamagishi M, Kawano M, and Mukaida N. Ablation of Ccr2 gene exacebates polyarthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum. 2011; 63 (1) : 96-106. (Abstract) (Supplemental Figures)
3. Inui M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, and Kondo T. Protective roles of CX3CR1-mediated signals in toxin A-induced
enteritis through the induction of heme oxygenase-1 expression. J Immunol 2011; 186 (1): 423-431. (Free text).
4. Shimizu K, Furuichi K, Sakai N, Kitagawa K, Matsushima K,, Mukaida N, Kaneko S, and Wada T. Fractalkine and its receptor, CX3CR1, promote hypertensive
interstitial fibrosis in kidney. Hypertension Res 2011; 34 (6): 747-752.
5. Chen Y, Chen L, Li J, Mukaida N, Wang Q, Yang C, Yin WJ, Zheng XH, Jin W, and Shao ZM. ERbeta and PEA3 co-activate IL-8 expression and promote the invasion of breast cancer cells. Cancer Biol Ther 2011; 11 (5): 497-511.
6. Nosaka M, Ishida Y, Kimuara A, Inui M, Mukaida N, and Kondo T. Absence of IFN-gamma acclerates thrombus resolution through
enhancing MMP-9 and VEGF expression. J Clin Invest 2011; 127 (7): 2911-2920. (Free text)
7. Liu G, Lu P, Li L, Jin H, Mukaida N, and Zhang X. Critical role of SDF-1 alpha-induced progenitor cell recruitment
and macrophage VEGF production in the experimental corneal neovascularization.
Mol Vis 2011; 17: 2129-2138.
8.Mukaida N, Wang Y-Y, and Li Y-Y. Roles of Pim-3, a novel survival kinase, in tumorigenesis.
Cancer Sci 2011; 102 (8): 1437-1442. (Invited Review)(Free Text-KURA)
9. Mukaida N, Sasaki S, and Popivanova BK. Tumor necrosis factor and chemokines in colitis-associated cancer. Cancers 2011; 3: 2811-2826.
2010
1. Oka M, Sakguchi M, Okada T, Ozaki M, Yoshioka T, Inoue H, Mukaida N, Kikkawa U and Nishigori C. Signal transducer and activator of transcription
3 (STAT3) upregulates interleukin-8 expression at the level of transcription
in human melanoma cells. Exp Dermatol 201; 19: e50-e55.
2. Kimura A, Ishida Y, Wada T, Hisaoka T, Morikawa Y, Sugaya T, Mukaida N, and Kondo T. The absence of interleukin-6 enhanced arsenite-induced renal
injury by promoting autophagey of tubular epithelial cells with aberrant
extracellular signal-regulated kinase activation. Am J Pathol 2010; 176 (1): 40-50 (Abstract).
3. Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, and Kaneko S. Enhancement of tumor-specific T cell responses by transcatheter arterial embolization with dendritic cells for hepatocellular carcinoma. Int J Cancer 2010; 126 (9): 2164-2174, (Abstract).
4. Li Y-Y, Wang Y-Y, Tanigucghi T, Kawakami T, Baba T, Ishibashi H, and Mukaida N. Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability. Int J Cancer 2010; 127 (2): 474-484 (Abstract)
5. Wu Y,Wang Y-Y, Nakamoto Y, Li Y-Y, Baba T, Kaneko S, Fujii C, and Mukaida N. Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in liver. Oncogene 2010; 29 (15): 2228-2237 (Abstract)(Free Tex-KURAt)
6.Takamatsu R, Teruya H, Takeshima E, Ishikawa C, Matsumoto K, Mukaida
N, Li J-D, Heuner K, Higa F, Fujita J, and Mori N. Molecular characterization
of Legionella pneumophila-induced interleukin-8 expression in T cells.
BMC Microbiol 2010; 10: 1.
7. Kostadinova FI, Baba T, Ishida Y, Kondo T, Popivanova BK, and Mukaida N. Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated
acute colitis in mice. J Leukocyte Biol 2010; 88: 133-143. (Abstract)
8. Iida N, Nakamoto Y, Baba T, Nakagawa H, Mizukoshi E, Naito M, Mukaida N, and Kaneko S. Antitumor effect after radiofrequency ablation of murine
hepatoma is augmented by an active variant of CC chemokine ligand 3/macrophage
inflammatory protein-1 alpha. Cancer Res 2010; 70 (16) 6556-6565 (Abstract)(Free Text-KURA)
9. Kakinoki K, Nakamoto Y, Kagaya T, Tsuchiyama T, Sakai Y, Nakahama T, Mukaida N, and Kaneko S. Prevention of intrahepatic metastasis of liver cancer by
suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1
delivery in mice. J Gene Med 2010; 12 (12): 1002-1013.
2009
1. Ishibe T, Kimura A, Ishida Y, Takayasu T, Hayashi T,
Tsuneyama K, Matsushima K, Sakata I, Mukaida N, and Kondo T. Recued acetaminophen-induced liver injury in mice
by genetic disruption of IL-1 receptor antagonist. Lab Invest 2009; 89 (1): 68-79 (Abstract)
2. Lu P, Li L, Lin G, van Rooijen N, Mukaida N, and Zhang X. Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. Cornea 2009; 28 (5): 562-569.
3. Li Y-Y, Wu Y, Tsuneyama K, Baba T, and Mukaida N. Essential contribution of Ets-1 to constitutive Pim-3 expression
in human pancreatic cancer cells. Cancer Sci 2009; 100 (3): 396-404. (Abstract)
4. Lu P, Li L, Lin G, van Rooijen N, Mukaida N, and Zhang X. nhanced corneal neovascularization along with aberrant
angiogenic factor expression in the absence of IL-1 receptor antagonist.
Invest Ophthalmol Vis Sci 2009; 50 (10): 4761-4768 (Abstract).
5. Baba T, Nakamoto Y, and Mukaida N. Crucial contribution of thymic Spir alpha+ conventional dendritic
cells to central tolerance against blood-borne antigens in a CCR2-dependent
manner. J Immunol 2009; 183 : 3053-3063 (Abstract).
6. Popivanova BK, Kostadinova FI, Furuichi K, Shamekh MM, Kondo T, Wada T, Egashira K, and Mukaida N. Blockade of CCL2, reduces chronic colitis-associated carcinogenesis
in mice. Cancer Res 2009; 69 (19): 7884-7892. (Abstract). (Free Tex-KURA)
7. Seo JY, Yu JH, Lim JW, Mukaida N, Kim H. Nitrix oxide-induced IL-8 expression is mediated by NF-kappaB
and AP-1 in gastric epithelial AGS cells. J Physiol Pharmacol 2009; 60 Suppl 7: 101-106.
2008
1. Zheng H-C, Tsuneyama K, Takahashi H, Miwa S, Sugiyama T, Popivanova BK, Fujii C, Nomoto K, Mukaida N, and Takano Y. Aberrant Pim-3 expression is invoveld in gastric adenoma-adenocarcinoma
sequence and cancer progression. J Cancer Res Clin Oncol 2008; 134 (4): 481-488.
2. Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, and Mukaida N. Blocking TNF-alpha reduces colorectal carcinogenesis associated with chrnoic colitis. J Clin Invest 2008; 118 (2): 560-570. (Abstract) (Full text)
3. Baba T, Iwasaki S, Suzuki A, Utano T, Ikeda H, Yoshiki T, Kasahara M, Ishizu
A. Rat CD4+CD8+ macrophages kill tumor cells through NKG2D- and granzyme/perforin-dependent
mechanism. J Immunol 2008; 180 (5): 2999-3006 (Abstract)
4. Lu P, Li L, Kuno K, Wu Y, Baba T, Li Y-Y, Zhang X, and Mukaida N. Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. J Immunol 2008; 180 (6): 4283-4291. (Abstract)
5. Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yashiro K, Moss
J, Hirayama T. Molecular characterization of Helicobacter pylori VacA induction
of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating
transcription factor-2, cAMP responsive element binding protein, and NF-kappaB
activation. J Immunol 2008; 180 (7): 5017-5027. (Abstract)
6. Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge JE, Abe J, Shono Y, Kitabatake M, Kakimi K, Mukaida N, Matsushima K. Chemokine-mediated rapid turnover of myeloid-derived suppressor
cells in tumor-bearing mice. Blood 2008; 111: 5457-5466. (Abstract) (Free Full text)
7. Furuichi K, Wada T, Kitajima S, Toyama T, Okumura T, Hara A, Kawachi
H, Shimizu F, Sugaya T, Mukaida N, Narumi S, Matsushima K, and Kaneko S,IFN-Inducible protein 10 (CXCL10) regulates tubular cell proliferation
in renal ischemia-reperfusion injury. Nephron Exp Nephrol 2008; 109 (1): c29-c38. (Abstract)
8. Tsuchiyama T, Nakamoto Y, Sakai Y, Mukaida N, Kaneko S. Optimal amount of monocyte chemoattractant protein-1 enhances
antitumor effects of suicide gene therapy against hepatocellular carcinoma
by M1 macrophage activation. Cancer Sci 2008; 99 (10): 2075-2082. (Abstract)
9. Iida N, Nakamoto Y, Baba T, Kakinoki K, Li Y-Y, Wu Y, Matsushima K, Kaneko S, and Mukaida N. Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine
receptor 1- and 5-dependent manner. J Leukocyte Biol 2008; 84 (4): 1001-1010. (Abstract)
10. Ishida Y, Hayashi T, Goto T, Kimura A, Akimoto S, Mukaida N, and Kondo T. Essential involvement of CX3CR1-mediated signals in the
bactericidal host defense during septic peritonitis. J Immunol 2008; 181 (6): 4208-4218. （Abstract).
11. Lu P, Li L, Wu Y, Mukaida N, and Zhang X. Essential contribution of CCL3 to alkali-induced corneal
neovascularization by regulating vascular endothelial growth factor production
by macrophages. Moｌ Vis 2008; 14: 1614-1622. (Abstract)
12. Wu Y, Li Y-Y, Matsushima K, Baba T, and Mukaida N. CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and
fibroblasts, and promotes angiogenesis in murine lung metastasis process. J Immunol 2008; 181 (9): 6384-6393. (Abstract)
2007
1. Edwards MR, Hewson CA, Laza-Stanca V, Lau H-TH, Mukaida N, Hershenson MB, and Johnston SL. Protein kinase R, IkappaB kinase beta
and NF-kappaB are required for human rhinovirus induced pro-inflammatory
cytokine production in bronchial epitheial cells. Mol Immunol 2007; 44 (7): 1598-1608 (Abstract).
2. Lu P, Li L, Mukaida N, and Zhang X. Alkali-induced corneal neovascularization occurrs indepdently
of CXCR2-mediated neutrophil infiltration. Cornea 2007; 26(2): 199-206.
3. Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, and Kaneko S. Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma. J Immunol 2007; 178 (1): 574-583 (Abstract).
4. Tachibana Y, Nakamoto Y, Mukaida N, and Kaneko S. Intrahepatic interleukin-8 production during disease progression
of chronic hepatitis C. Cancer Lett 2007; 251: 36-42.
5. Popivanova BK, Li Y-Y, Zheng H, Omura K, Fujii C, Tsuneyama K, and Mukaida N. A proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci 2007; 98 (3): 321-328(Abstract).
6. Nakamoto Y, Mizukoshi E, Tsuji H, Sakai Y, Kitahara M, Arai K, Yamashita
T, Yokoyama K, Mukaida N, Matsushima K, Matsui O, and Kaneko S. Combined therapy of transcather
hepatic arterial embolization with intratumoral dendritic cell infusion
for hepatocellular carcinoma; clinical safety. Clin Exp Immunol 2007; 147 (2): 296-305.
7. Tucker RM, Hendrickson RJ, Mukaida N, Gill RG, and Mack CL. Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia (BA). Viral Immunol 2007; 20 (1): 34-43
8. Yoshida N, Katada K, Handa O, Takagi T, Kokura S, Naito Y, Mukaida N, Soma T, Shimada Y, Yoshikawa T, and Okanoue T. Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells. Int J Mol Med 2007; 19 (2): 335-340.
9. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima
K, and Mukaida N. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5
axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage
and fibrocyte infiltration. Am J Pathol 2007; 170 (3) : 843-854 (Abstract). (Full text)
10. Hayashi T, Ishida Y, Kimura A, Iwakura Y, Mukaida N, and Kondo T. IFN-gamma protects cerulein-induced acute pancreatitis by
repressing NF-kappaB activation. J Immunol 2007; 178: 7385-7394 (Abstract).
11. Teruya H, Higa F, Akamine M, Ishikawa C, Okudaira T, Tominori K, Mukaida N, Tateyama M, Heuner K, Fujita J, and Mori N. Mechanisms of Legionella
pneumophila-induced interleukin-8 expression in human lung epithelial cells.
BMC Microbiology 2007; 7: 102. (Abstract)
2006
1. Yang X,Lu P, Ishida Y, Kuziel WA, Fujii C, and Mukaida N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant
reduction in the accumulation of hepatic stellate cells, macrophages, and
neovascularization. Intl. J. Cancer 2006; 118(2): 335-45. (Abstract)
2. Kagaya T, Nakamoto Y, Sakai Y, Tsuchiyama T, Yagita H, Mukaida N and Kaneko S. Monocyte chemoattractant protein-1 gene delivery enhances
antitumor effects of herpes simlex virus thymidine kinase/ganciclovir system
in a model of colon cancer. Cancer Gene Ther 2006; 13 (4): 357-366. (Abstract)
3. Yang X,Lu P, Fujii C, Nakamoto Y, Gao J-L, Kaneko S, Murphy PM, and Mukaida N. Essential contribution of a chemokine, CCL3, and its receptor, CCR1,
to hepatocellular carcinoma progression. Intl J Cancer 2006; 118 (2): 1869-1876. (Abstract).
4. Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu and Mukaida N. Opposite roles of neutrophils and macrophages in the pathogenesis
of acetaminophen-induced acute liver injury. Eur J Immunol 2006; 36 (4): 1028-1038. (Abstract)
5. Ishida Y, Kondo T, Kimura A, Matsushima K, and Mukaida N. Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta singal pathway. J Immunol 2006; 176: 5598-5606. （Abstract)
6. Li Y-Y, Popivanova BK, Nagai Y, Ishikura H, Fujii C, and Mukaida N. Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly
expressed in human pancreatic cancer and phosphoyrlates Bad to block Bad-mediated
apoptosis in human pancreatic cancer cell lines. Cancer Res 2006; 66 (13): 6741-6747 (Abstract).
7. Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, and Kondo T. Interferon-gamma plays protective roles in sodium arsenite-induced
renal injury by up-regulation of intrarenal multidrug resistance-associated
protein 1 epxression. Am J Pathol 2006; 169 (4): 1118-1128. (Abstract). (Full text)
8. Yoshida N, Imamoto E, Uchiyama K, Kuroda M, Naito Y, Mukaida N, Kawabe A, Shimada Y, Yoshikawa T, and Okanoue T. Molecular mechanisms involved in interleukin-8 production by normal human oesophageal epithelial cells. Aliment Pharmacol Ther Sym Ser 2006; 2: 219-226.
9. Yamashima T, Popivanova BK, Guo J, Kotani S, Wakayama T, Iseki S, Sawamonoto K, Okano H, Fujii C, Mukaida N, and Tonchev A. Implication of Down syndrome cell adhesion molecule in
hippocampal neurognesis of ischemic monkeys. Hippocampus 2006; 16: 924-935.
2005
1. Kimura A, Ishida Y, Wada T, Yokoyama H, Mukaida N, and Kondo T. MRP-1 expression levels determine strain-specific
susceptibility to arsenic-induced renal injury between C57BL/6 and BALB/c
mice. Toxicol.Appl. Pharmacol 2005; 203: 53-61.
2. Fujii C, Nakamoto Y, Lu P, Tsuneyama K, Popivanova B, Kaneko S, and Mukaida N. Aberrant expression of serine/ threoninekinase Pim-3 in hepatocellular
carcinoma development and its role in the proliferation of human hepatoma
cell lines. Intl. J. Cancer 2005; 114: 209-218. (Abstract)
3. Iizasa H, Yoneyama H, Mukaida N, Kataoka Y, Naito M, Yoshida N, Nakashima E, and Matsushima K. Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with Th2 cytokine production. J. Immunol. 2005; 174 (5) 3273-3280. (Abstract)
4. Edwards MR, Mukaida N, JohnsonM,and Johnston SL. IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids. Pulmon. Ther. Pharmacol 2005; 18: 227-445.
5. Sato K, Imai Y, Higashi N, Kumamoto Y, Mukaida N, and Irimura T. Redistributions of macrophages expressing the macrophage
galactose-type C-type lectin (MGL) during antigen-induced chronic granulation
tissue formation. Intl Immunol 2005; 17: 559-568.
6. Kurashima K, Tamura J, Fujimura M, Qiu Z, Nakao S, and Mukaida N. Reduced serum antibody production and acute airway inflammation in interleukin-6-deficient
mice challenged with ovalibumin. Allergology Intl 2005; 54: 331-338.
7. Kuroda T, Kitadai Y, Tanaka S, Yang X, Mukaida N, Yoshihara M, and Chayama K. Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment. Clin Cancer Res 2005; 11: 7629-7635. (Abstract)
2004
1. Nakamura M, Kyo S, Kanaya T, Yatabe N, Maida Y, Tanaka M, Ishida Y, Fujii C, Kondo T, Inoue M, and Mukaida N. hTERT-promoter-based tumor-specific expression of MCP-1 effectively
sensitizes cervical cancer cells to a low dose of cisplatin. Cancer Gene Ther 2004; 11(1):1-7. (Abstract)
2. Ishida Y, Kondo T, Tsuneyama K, Lu P, Takayasu T, and Mukaida, N. The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced
liver injury in mice. J. Leukocyte Biol 2004; 75 (1): 59-67. (Abstract)
3. Amano H, Morimoto K, Senba M, Wang H, Ishida Y, Kumatori A, Yoshimine H, Oishi K, Mukaida N, and Nagatake T. Essential contribution of monocyte chemoattractant
protein (MCP)-1/C-C chemokine ligand-2 to resolution and repair process
in acute bacterial pneumonia. J Immunol 2004; 172 (1): 398-409.(Abstract)
4. Ishida Y, Kondo T, Takayasu T, Iwakura Y, and Mukaida N. The essential involvement of cross-talk between IFN-g and TGF-b
in the skin wound-healing process. J Immunol 2004; 172 (3): 1848-1855. (Abstract)
5. Ishida Y, Maegawa T, Kondo T, Kimura A, Iwakura Y, Nakamura
S, and Mukaida N. Essential involvement of IFN-gamma in Clostridium difficile toxin
A-induced enteritis. J Immunol 2004; 172 (5): 3018-3025. (Abstract)
6. Wada T, Furuichi K, Sakai N, Iwata Y, Kitagawa K, Ishida
Y, Kondo T, Hashimoto H, Ishikawa Y, Mukaida N, Tomosugi N, Matsushima K, Egashira K, and Yokoyama H. Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. J Am Soc Nephrol 2004; 15 (4): 940-948.
7. Ryoo S, Won M, Kim DU, Kim L, Han G, Park SK,
Mukaida N, Maeng P, Yoo HS, and Hoe KL. PPARa activation abolishes LDL-stimulated
IL-8 production via AP-1 deactivation in human aortic smooth muscle cells. Biochem Biophys Res Commun 2004; 318: 329-334..
8. Hwang YS, Jeong M, Park JS, Kim MH, Lee DB, Shin BA, Mukaida N, Ellis LM, Kim HR, Ahn BW, and Jung YD. Interleukin-1beta stimulates
IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma
cells. Oncogene 2004; 23: 6603-6611.
9. Kitagawa K, Wada T, Iwata Y, Kitagawa K, Kobayashi
K, Tomosugi N, Matsushima K, Mukaida N, and Yokoyama H. Blockade of CCR2 ameliorates progressive fibrosis.
Am. J. Pathol. 165: 237-246, 2004. (Abstract)
10. Qiu Z, Fujimura M, Kurashima K, Nakao S, and Mukaida N. Enhanced airway inflammation and decreased subepithelial fibrosis in
interleukin 6-deficient mice following chronic exposure to aerosolized
antigen. Clin Exp Allergy 2004; 34: 1321-1328.
11. Imamura R, Konaka K, Matsumoto N, Hasegawa M,
Fukui M, Mukaida N, Kinoshita T, and Suda T. Fas ligand induces cell-autonomous NF-k
B activation and IL-8 production by a mechanism distinct from that of TNF-alpha.
J Biol Chem 2004; 279(45): 46415-46423.
12. Tomita Y, Yang X, Ishida Y, Nemoto-Sasaki Y, Kondo T, Oda M, Watanabe G, Chladakov GN, Fujii C, and Mukaida N. Spontaneous regression of lung metastasis in the absence of tumor
necrosis factor receptor p55. Intl J Cancer 2004; 112 (6): 927-933.(Abstract)
13. Kitamura K, Nakamoto Y, Kaneko S, and Mukaida, N. Pivotal roles of interleukin-6 in transmural inflammation in murine
T cell transfer colitis. J Leukocyte Biol 2004; 76 (6): 1111-1117.(Abstract)
14. Yanaba K, Mukaida, N, Matsushima K, Murphy PM, Takehara K, and Sato S. A role of C-C chemokine receptors 1 and 5 and macrophage inflammatory protein-1a on the cutaneous Arthus reaction: Possible attenuation of their inhibitory effects by compensatory production. Eur J Immunol 2004; 34 (12): 3553-3561. (Abstract)
15. Mukaida N. Chemokines. In The Encylopedia of Endocrine Diseases, Four-Volume Set (Martini L Editor-in-Chief), Elsevier Science Ltd, London, UK, vol. 1,
pp.490-494, 2004.
16. Mukaida N. Cancer gene therapy using cytokine and chemokine genes. Ann Cancer Res Ther 2004; 12 (1 & 2): 33-51.
2003
1. Wang H, Nemoto-Sasaki Y, Kondo T, Akiyama M, and Mukaida N. Potential involvement of monocytechemoattractant protein (MCP)-1/CCL2 in IL-4-mediated tumor immunity through inducing dendritic cell migration into the draining lymph nodes. Int Immunopharmacol. 2003; 3: 627-642. (Abstract)
2. Kim H, Seo JY, Lim JW, Mukaida N, and Kim KH. Helicobacter pylori-induced IL-8 expression in AGS cells: mediation by NF-kB and AP-1. Dig Dis Sci 2003; 48: 257-265.
3. Tsuchiyama T, Kaneko S, Nakamoto Y, Sakai Y, Honda
M, Mukaida N, and Kobayashi K. Enhanced anti-tumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidinekinase and monocytechemoattractant protein-1 against hepatocellular carcinoma. Cancer Gene Ther 2003; 10(4):260-269. (Abstract)
4. Furuichi K, Wada T, Iwata Y, Kitagawa K, Kobayashi K, Hashimoto
H, Ishiwata Y, Tomosugi N, Mukaida N, Matsushima K, Egashira K, and Yokoyama H. Gene therapy expressing
amino-terminal truncated monocytechemoattractant protein-1 prevents renal
ischemia-reperfusion injury. J Am Soc Nephrol 2003; 14: 1066-1071.
5. Lu P, Nakamoto Y, Nemoto-Sasakai Y, Fujii C, Wang H, Hashii M, Ohmoto Y, Kaneko S, Kobayashi K, and Mukaida N. Potential interaction between CCR1 and its ligand, CCL3, induced
by endogenously produced interleukin-1, in human hepatomas. Am J Pathol 2003; 162: 1249-1258. （Abstract)
6. Popivanova BK, Koike K, Tonchev AB, Ishida Y, Kondo T, Ogawa S, Mukaida N, Inoue M, and Yamashima T. Accumulation of microglial cells expressing
ELR motif-positive CXC chemokines and their receptor CXCR2 in monkey hippocampus
after ischemia-reperfusion. Brain Res 2003; 970: 195-204. (Abstract)
7. Lin Z-Q, Kondo T, Ishida Y, Takayasu T, and Mukaida N. Essential involvement of IL-6 in skin wound healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukocyte Biol 2003; 73(6):713-721.
8. Inaoki M, Sato F, Shirasaki F, Mukaida N, and Takehara K. The frequency of type 2 CD8+ T cells is increased
in peripheral blood from patients with psoriasis vulgaris. J Clin Immunol 2003; 23(4): 269-278.
9. Kuwada Y, Sasaki T, Morinaka K, Kitadai Y, Mukaida N, and Chayama K. Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. Int J Oncol 2003; 22(4):765-771.
10. Ohta M, Kitadai Y, Tanaka S, Yoshihara M, Yasui W, Mukaida N, Haruma K, and Chayama K. Monocytechemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int J Oncol 2003; 22(4): 773-778.
11. Furuichi K, Wada T, Iwata Y, Kitagawa K, Kobayashi K-i,
Hashimoto H, Ishiwata Y, Asano M, Wang H, Matsushima K, Takeya M, Kuziel
WA, Mukaida N, and Yokoyama H. CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol 2003; 14 (10) : 2503-2515. (Abstract)
12. Mukaida N. The pathophyiological roles of interleukin (IL)-8/CXCL8 in pulmonary
diseases. Am J Physiol Lung Cell Molec Physiol 2003; 284: L566-L577. (Abstract)
13. Mukaida N, Ketlinsky SA, and Matsushima K. Interleukin-8 and other CXC chemokines. In The Cytokine Handbook (Thomson A and Lotze MT eds.), Elsevier Science Ltd, London, UK, pp. 1049-1081,
2003.
2002
1. Furuichi K, Wada T, Iwata Y, Sakai N, Yoshimoto K,
Kobayashi Ki, Mukaida N, Matsushima K, and Yokoyama H. Administration of FR167653, a new anti-inflammatory
compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant 2002; 17: 399-407.
2. Kitamura K, Nakamoto Y, Akiyama M, Fujii C, Kondo T, Kobayashi Ki, Kaneko S, and Mukaida N. Pathogenic roles of tumor necrosis factor receptor p55-mediated signals
in dimethylnitrosamine-induced murine liver fibrosis. Lab Invest 2002; 82: 571-583. (Abstract)
3. Mori R, Kondo T, Ohshima T, Ishida Y, and Mukaida N. Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration. FASEB J 2002; 16: 963-974. (Abstract)
4. Ishida Y, Kondo T, Ohshima T, Fujiwara H, Iwakura Y, and Mukaida N. A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury. FASEB J 2002; 16: 1227-1236. (Abstract)
5. Sakai N, Wada T, Furuichi K, Iwata Y, Yoshimoto K,
Kitagawa K, Kokubo S, Kobayashi M, Takeda S, Kida H, Kobayashi K, Mukaida N, Matsushima K, and Yokoyama H. p38 MAPK phosphorylation and NF-kappaB
activation in human crescenticglomerulonephritis. Nephrol Dial Transplant 2002; 17: 998-1004.
6. Jung YD, Fan F, McConkey DJ, Jean ME, Liu W, Reinmuth N,
Stoeltzing O, Ahmad SA, Parikh AA, Mukaida N, and Ellis LM. Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced
IL-8 expression in human vascular smooth muscle cells. Cytokine 2002; 18: 206-213.
7. Ato M, Iwabuchi K, Shimada S, Mukaida N, and Onoe K. Augmented expression of tumour necrosis factor-alpha induced by lipopolysaccharide in spleen of human monocytechemoattractant protein-1 transgenic mouse enhances the lipopolysaccharide sensitivity of the marginal zone macrophages. Immunology 2002; 106: 554-563.
8. Ohta M, Kitadai Y, Tanaka S, Yoshihara M, Yasui W,
Mukaida N, Haruma K, and Chayama K. Monocytechemattractant protein-1 (MCP-1) expression
correlates with macrophage infiltration and tumor vascularity in human
esophageal squamous cell carcinomas. Int J Cancer 2002; 102: 220-224.
9. Kitakata H, Nemoto-Sasaki Y, Takahashi Y, Kondo T, Mai M, and Mukaida N. Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells. Cancer Res 2002; 62 : 6682-6687. (Abstract)
10. Fujii H, Hasegawa M, Takehara K, Mukaida N, and Sato S. Abnormal expression of intracellular cytokines and chemokine
receptors in peripheral blood T lymphocytes from patients with systemic
sclerosis. Clin Exp Immunol 2002; 130 : 548-556.
11. Ohya JY, Matsuoka H, Mukaida N, Kasahara T, and Ishii A. Growth inhibition of Plasmodium falciparum
and interleukin-8 production by peripheral blood mononuclear and polymorphonuclear
cells in vitro. Jpn J Trop Med Hyg 2002; 30: 351-355.
2001
1. Nakatani T, Kaburagi Y, Shimada Y, Inaoki M, Takehara K,
Mukaida N, and Sato S. CCR4 memory CD4 T lymphocytes are increased in peripheral
blood and lesional skin from patients with atopic dermatitis. J Allergy Clin Immunol 2001; 107: 353-358.
2. Shinohara T, Miki T, Nishimura N, Nokihara H, Hamada H, Mukaida N, and Sone S. Nuclear factor-kappaB-dependent expression of metastasis
suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53.
Cancer Res 2001; 61: 673-678. (Abstract)
3. Polyak SJ, Khabar KSA, Paschal DM, Ezelle HJ, Duverlei
G, Barber GN, Levy DE, Mukaida N, and Gretch DR. : Hepatitis C virus nonstructural 5A protein induces interleukin-8,
leading to partial inhibition of the interferon-induced antiviral response. J Virol 2001; 75: 6095-6106. (Abstract)
4. Zhang X, Wang JM, Gong WH, Mukaida N, and Young HA. Differential regulation of chemokine gene expression by
15-deoxy-D12,14 prostaglandin J2. J Immunol 2001; 166: 7104-7111.(Abstract)
5. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, and Phipps RP. IL-8 production in human lung fibroblasts
and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl
homoserine lactone is transcriptionally regulated by NF-kappaB and activator
protein-2. J Immunol 2001; 167: 366-374 (Abstract)
6. Wolf JS, Chen Z, Dong G, Sunwoo JB, Bancroft CC, Capo
DE, Yeh NT, Mukaida N, and Van Waes C. IL (interleukin)-1alpha promotes nuclear factor-kappaB
and AP-1-induced IL-8 expression, cell survival, and proliferation in head
and neck squamous cell carcinoma. Clin. Cancer Res 2001; 7: 1812-1820. (Abstract)
7. de Wynter EA, Heyworth CM, Mukaida N, Matsushima K, and Testa NG. NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor. Leukemia 2001; 15: 1092-1101.
8. Hiraoka S, Miyazaki Y, Kitamura S, Toyota M, Kiyohara T, Shinomura Y, Mukaida N, and Matsuzawa Y. Gastrin induces CXC chemokine expression in gastric
epithelial cells through activation of NF-kappaB. Am J Physiol Gastrointest Liver Physiol 2001; 281(3): G735-G742.
9. de Wynter EA, Heyworth CM, Mukaida N, Jaworska E, Weffort-Santos A, Matsushima K, and Testa NG. CCR1 chemokine
receptor expression isolates erythroid from granulocyte-macrophage progenitors.
J Leukocyte Biol 2001; 70(3): 455-460.
10. Sakai Y, Kaneko S, Nakamoto Y, Kagaya T, Mukaida N, and Kobayashi K. Enhanced anti-tumor effects of herpes simplex virus
thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant
protein-1 in hepatocellular carcinoma. Cancer Gene Ther 2001; 8: 695-704. (Abstract)
11. Satoh S, Oishi K, Iwagaki A, Senba M, Akaike
T, Akiyama M, Mukaida N, Matsushima K, and Nagatake T. Dexamethasone impairs pulmonary defence
against Pseudomonas aeruginosa through suppressing iNOS gene expression
and peroxynitrite production in mice. Clin Exp Immunol 2001; 126: 266-273.
12. Wada T, Furuichi K, Sakai N, Hisada Y, Kobayashi K, Mukaida N, Tomosugi N, Matsushima K, and Yokoyama H. Involvement of p38 mitogen-activated
protein kinase followed by chemokine expression in crescentic glomerulonephritis.
Am J Kidney Dis 2001; 38: 1169-1177.
2000
1. Ato M, Iwabuchi K, Matsui N, Mukaida N, Iwabuchi C, Takahashi A, Takayanagi T, Dongdog E-M, Hatakeyama S, Ishikura
H, Kato M, Negishi I, Nishihori H, Watano K, Ogasawara K, Matsushima K,
Onoe K. Delayed clearance of zymogen-indcuedgranuloma and depressed phagocytosis
of macrophages with concomitant up-regulated kinase activities of src-family
in a human monocytechemoattractant protein-1 transgenic mouse. Immunobiology 2000; 201: 432-449.
2. Abe S, Nakamura H, Inoue S, Takeda H, Saito H, Kato S, Mukaida N, Matsushima K, and Tomoike H. Interleukin-8 gene repression by clarithromycin
by AP-1 binding site in human brochnial epithelial cells. Am J Respir Cell Mol Biol 2000; 22: 51-60.
3. Lee LF, Hellendall RP, Wang Y, Haskill JS, Mukaida N, Matsushima K, and Ting JP. IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration. J Immunol 2000; 164: 2769-2775. (Abstract)
4. Amano H, Yamamoto H, Senba M, Oishi K, Suzuki
S, Fukushima K, Mukaida N. Matsushima K, Eguchi K, and Nagatake T. Impairment of endotoxin-induced
macrophage inflammatory protein 2 gene expression in alveolar macrophages
in streptozotocin-induced diabetes in mice. Infect Immun 2000; 68: 2925-2929.
5. Ueno M, Sonoda Y, Funakoshi M, Mukaida N, Nose K, and Kasahara T. Differential induction of JE/MCP-1 in subclones
from a murine macrophage cell line, RAW 254.7: Role of kB-3 binding protein.
Cytokine 2000; 12: 203-219.
6. Wada T, Furuichi K, Sakai N, Iwata Y, Yoshimoto K,
Shimizu M, Kobayashi KI, Mukaida N, Matsushima K, and Yokoyama H. A new anti-inflammatory compound, FR167653, ameliorates crescenticglomerulonephritis in Wistar-Kyoto rats. J Am Soc Nephrol 2000; 11: 1534-1541.
7. Kitadai Y, Haruma K, Mukaida N, Ohmoto Y, Matsutani N, Yasui W, Yamamoto S, Sumii K, Kajiyama G, Fidler
IJ, and Tahara E. Regulation of disease-progression genes in human gastric
carcinoma cells by interleukin 8. Clin Cancer Res 2000; 6: 2735-2740.
8. Furuichi K, Wada T, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, Kobayashi
KI, Takasawa K, Kida H, Takeda S, Mukaida N, Matsushima K, and Yokoyama H. : Distinct expression of CCR1 and CCR5
in glomerular and interstitial lesions of human glomerular diseases. Am J Nephrol 2000; 20: 291-299.
9. Wada T, Furuichi K, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, Takeda SI, Takasawa K, Yoshimura M, Kida H, Kobayashi KI, Mukaida N, Naito T, Matsushima K, and Yokoyama H. : Up-regulation of monocytechemoattractant
protein-1 in tubulointerstitial lesions of human diabetic nephropathy.
Kidney Int 2000; 58: 1492-1499.
10. Ostergaard C, Yieng-Kow RV, Larsen CG, Mukaida N, Matsushima K, Benfield T, Frimont-Moller N, Espersen F, Kharazmi A, and
Lundgren JD. : Treatment with a monoclonal antibody to IL-8 attenuates
the pleocytosis in experimental pneumococcal meningitis in rabbits when
given intravenously, but not intracisternally. Clin Exp Immunol 2000; 122: 207-211.
11. Iguchi A, Kitajima I, Yamakuchi M, Ueno S, Aikou T, Kubo T, Matsushima K, Mukaida N, and Maruyama I. PEA3 and AP-1 are required for constitutive IL-8 gene
expression in hepatoma cells. Biochem Biophys Res Commun 2000; 279: 166-171. (Abstract)
12. Murayama T, Mukaida N, Sadanari H, Yamaguchi N, Khabar KS, Tanaka J, Matsushima K, Mori S, and
Eizuru Y. The immediate early gene 1 product of human cytomegalovirus
is sufficient for up-regulation of interleukin-8 gene expression.
Biochem Biophys Res Commun 2000; 279: 298-304. (Abstract)
13. Nokihara H, Yanagawa H, Nishioka Y, Yano S, Mukaida N, Matsushima K, and Sone S. Natural killer cell-dependent suppression of systemic spread of human lung adenocarcinoma cells by monocytechemoattractant protein-1 gene transfection in severe combined immunodeficient mice. Cancer Res 2000; 60: 7002-7007. (Abstract)
14. Jiang S, Naito M, Kaizu C, Kuwata K, Hasegawa G, Mukaida N, and Shultz LD. Lipopolysaccharide-induced cytokine and receptor expression
and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant
mice. Liver 2000; 20: 465-474.
15. Nishihori H, Tsuji H, Wang H, Tahara H, Akiyama M, Ogawa Y, Matsushima K, Iwakura Y, and Mukaida N. Participation of endogenously produced interferon gamma in interleukin-4-mediated
tumor rejection. Hum Gene Therapy 2000; 11: 659-668. (Abstract)
16. Mukaida N. Interleukin-8: an expanding universe beyond neutrophil chemotaxis
and activation. Int J Hematol 2000; 72: 391-398. (Abstract)
17. Khabar KSA, Murayama T, al-Ahdal MN, Mukaida N, and Matsushima K. Interleukin-8 (IL-8) is induced by viruses, enhances cytomegalovirus and picornavirus replication and inhibits the antiviral action of interferon-a. In Advances in Animal Virology (Jameel S and Villarreal L. eds.), Science Publisher Inc, Enfield, USA, pp. 323-335, 2000.
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