Organization

Division of Epithelial Stem Cell Biology

Staff

Nicholas Barker

Research Professor
Nicholas Barker

Summary

 We employ a variety of genetic mouse models, including in-vivo lineage tracing, and ex-vivo organoid culture methods to dissect the role of Lgr5-expressing stem cells in epithelial self-renewal and cancer of various organs, including the stomach, ovary and mammary gland. The ultimate goal is to harness the regenerative capacity of these adult stem cells for therapeutic use, as well as developing ways of blocking the cancer-promoting activities of mutated Lgr5 stem cells.

Figures

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Evaluating adult stem cell identity and behaviour during epithelial homeostasis and disease using ex-vivo organoid culture and in-vivo clonal lineage tracing technologies