共同研究成果

共同研究概要

論文

  1. Ueno M, Sugiyama H, Li F, Nishimura T, Arakawa H, Chen X, Cheng X, Takeuchi S, Takeshita Y, Takamura T, Miyagi S, Toyama T, Soga T, Masuo Y, Kato Y, Nakamura H, Tsujiguchi H, Hara A, Tajima A, Noguchi-Shinohara M, Ono K, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Maeda K, Ogoshi T, Hirao A. A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite. Analytical Chemistry. 2024; 96(36): 14499-14507. doi: 10.1021/acs.analchem.4c02653.

  2. Aoki K, Higuchi T, Akieda Y, Matsubara K, Ohkawa Y, Ishitani T. Mechano-gradients drive morphogen-noise correction to ensure robust patterning. Science Advances. 2024; 10: eadp2357. doi: 10.1126/sciadv.adp2357.

  3. Matsumoto K, Akieda Y, Haraoka Y, Hirono N, Sasaki H, Ishitani T. Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nature Communications. 2024; 15(1): 10662. doi: 10.1038/s41467-024-55108-x.

  4. Takatsuka R, Suzuki R, Terashima M, Suphakhong K, Takino T, Kawashiri S, Suzuki T. m6A reader IGF2BP3 contributes to gefitinib resistance in lung adenocarcinoma cells by modulating SNAI2 expression. Gene Reports. 2025; 38: 102113. doi: 10.1016/j.genrep.2024.102113.

  5. Ishikawa-Yamauchi Y, Emori C, Mori H, Endo T, Kobayashi K, Watanabe Y, Sagara H, Nagata T, Motooka D, Ninomiya A, Ozawa M, Ikawa M. Age-associated aberrations of the cumulus-oocyte interaction and in the zona pellucida structure reduce fertility in female mice. Communications Biology. 2024; 7: 1692. doi: 10.1038/s42003-024-07305-z.

  6. Sakoda T, Kikushige Y, Irifune H, Kawano G, Harada T, Semba Y, Hayashi M, Shima T, Mori Y, Eto T, Kamimura T, Iwasaki H, Ogawa T, Yoshimoto G, Kato K, Maeda T, Miyamoto T, Akashi K. TIM-3 marks measurable residual leukemic stem cells responsible for relapse after allogeneic stem cell transplantation. Cancer Science. 2024; 116(3): 698-709. doi: 10.1111/cas.16431.

  7. Nakano Y, Johmura Y. Functional diversity of senescent cells in driving ageing phenotypes and facilitating tissue regeneration. The Journal of Biochemistry. 2025; 177(3): 189-195. doi: 10.1093/jb/mvae098.

  8. Nakagawa T, Emori C, Ikawa M. Trophectoderm-specific gene manipulation using adeno-associated viral vectors. Experimental Animals. 2025. doi: 10.1538/expanim.24-0165 (Epub ahead of print).

  9. 高倉 伸幸. Review トピック (1)「医学薬学の接点 : 基礎研究成果を臨床現場へ」：血管新生の制御による血管病に対する治療. JCVA会誌：心血管薬物療法. 2025; 12(1): 5-10.

  10. Takii A, Tanabe Y, Li W, Shiomi H, Inoue A, Muramatsu F, Jia W, Takakura N. CD157+ vascular endothelial cells derived from human-induced pluripotent stem cells have high angiogenic potential. Infammation and Regeneration. 2025; 45(1): 14. doi: 10.1186/s41232-025-00379-0.

  11. Jing Y, Kobayashi M, Shoulkamy MI, Zhou M, Vu HT, Arakawa H, Sabit H, Iwabuchi S, Vu CQ, Kasahara A, Ueno M, Tadokoro Y, Kurayoshi K, Chen X, Yan Y, Arai S, Hashimoto S, Soga T, Todo T, Nakada M, Hirao A. Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma. Nature Communications. 2025; 16: 2876. doi: 10.1038/s41467-025-56946-z.

  12. Hongu T, Sarenqiqige, Shandan, Kusunoki H, Ishimura A, Suzuki T, Oskarsson T, Gotoh N. Permeable Lung Vasculature Creates Chemoresistant Endothelial Niche by Producing SERPINE1 at Breast Cancer Metastatic Sites. Cancer Science. 2025; 116(6): 1604-1615. doi: 10.1111/cas.70050.

  13. Tochinai R, Suzuki T, Tomita K, Sekizawa SI, Okada Y, Taki Y, Kuwahara M, Mutoh T. Localized pulmonary vascular changes in a mouse model of subarachnoid hemorrhage created by combining filament perforation and blood injection. Microvascular Research. 2025; 160: 104810. doi: 10.1016/j.mvr.2025.104810.

  14. Aoki K, Ishitani T. Mechanical force-driven cell competition ensures robust morphogen gradient formation. Seminars in Cell & Developmental Biology. 2025; 170: 103607. doi: 10.1016/j.semcdb.2025.103607. (Epub).

  15. Lyu H, Ishimura A, Suzuki R, Buyanbat K, Batbayar G, Meguro-Horike M, Horike SI, Yano S, Suzuki T. HDAC5, an early osimertinib-responsive gene, is a novel therapeutic target for the drug resistance in EGFR-mutant lung adenocarcinoma cells. Biochemistry and Biophysics Reports. 2025; 42: 102016. doi: 10.1016/j.bbrep.2025.102016.

  16. Fitriana N. Rahmawati, Nobuyuki Takakura. Development and aging of resident endothelial stem cells in pre-existing blood vessels. Experimental Hematology. 2025; 104795. doi: 10.1016/j.exphem.2025.104795.

  17. Suzuki H, Kunimatsu Y, Yoshioka Y, Asa M, Yamasaki S, Sugita M, Morita D. TAP-independent induction of N-myristoylated lipopeptide-specific CTLs in transgenic mice expressing the rhesus MHC class I allomorph, Mamu-B*098. The Journal of Immunology. 2025; 7: vkaf082. doi: 10.1093/jimmun/vkaf082. (Epub ahead of print).

  18. Ikeda Y, Kondo M, Suehiro JI, Oshima H, Kok SY, Takahashi K, Pauty J, Wang D, Sakurai H, Watabe T, Oshima M, Matsunaga YT. A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation. iScience. 2025; 28(6): 112517. doi: 10.1016/j.isci.2025.112517.

  19. Kitano T, Okumura S, Matsumoto T, Tsunoda S, Nishigori T, Obama K, Hara E. The Involvement of Oral Pathogenic Bacteria, Fusobacterium nucleatum Subspecies animalis in the Pathogenesis of Human Esophageal Adenocarcinoma. Gastro Hep Advances. 2025; 4(7): 100660. doi: 10.1016/j.gastha.2025.100660.

  20. (Mashiko D, Tonai S, Miyata H, Matzuk MM, Ikawa M. SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice. bioRxiv [Preprint]. 2025; 15: 653469. doi: 10.1101/2025.05.12.653469.)

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