私たちが発表した論文のうち、2002年以降に発表したものを紹介します。
2001年以前の論文については、こちらからご覧ください。

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T and Suzuki T. m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-beta-induced epithelial-mesenchymal transition of lung cancer cells. J Biol. Chem., 298: 102554, 2022. Wanna-Udom S, Terashima M, Suphakhong K, Ishimura A, Takino T and Suzuki T. KDM2B is involved in the epigenetic regulation of TGF-β-induced epithelial-mesenchymal transition in lung and pancreatic cancer cell lines. J Biol. Chem., 296: 100213, 2021. Takeuchi Y, Kimura N, Murayama T, Machida Y, Iejima D, Nishimura T, Terashima M, Wang Y, Li M, Sakamoto R, Yamamoto M, Itano N, Inoue Y, Ito M, Yoshida N, Inoue J, Akashi K, Saya H, Fujita K, Kuroda M, Kitabayashi I, Voon D, Suzuki T, Tojo A and Gotoh N. The membrane-linked adaptor FRS2b fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis. Proc Natl Acad Sci, USA., 118(43): e2103658118, 2021. Yamahana H, Terashima M, Takatsuka R, Asada C, Suzuki T, Uto Y and Takino T. TGF-beta1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells. Biochem Biophys Rep., 27:101072, 2021. Wanna-udom S, Terashima M, Lyu H, Ishimura A, Takino T, Sakari M, Tsukahara T and Suzuki T. The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB. Biochem Biophys Res Commun., 524(1): 150-155, 2020. Wang R, Yamada T, Kita K, Taniguchi H, Arai S, Fukuda K, Terashima M, Ishimura A, Nishiyama A, Tanimoto A, Takeuchi S, Ohtsubo K, Yamashita K, Yamano T, Yoshimura A, Takayama K, Kaira K, Taniguchi Y, Atagi S, Uehara H, Hanayama R, Matsumoto I, Han X, Matsumoto K, Wang W, Suzuki T and Yano S. Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer. Nat Commun., 11(1):4607, 2020. Sakai K, Nishiuchi T, Tange S, Suzuki Y, Yano S, Terashima M, Suzuki T and Matsumoto K. Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion. Sci Rep., 10(1):16678, 2020. Saifullah, Sakari M, Suzuki T, Yano S and Tsukahara T. Effective RNA knockdown using CRISPR-Cas13a and molecular targeting od the EML4-ALK transcript in H3122 lung cancer cells. Int J Mol Sci., 21(23):e8904, 2020. Yamahana H, Takino T, Endo Y, Yamada H, Suzuki T and Uto Y. A novel celecoxib analog UTX-121 inhibits HT1080 cell invasion by modulating membrane-type 1 matrix metalloproteinase. Biochem Biophys Res Commun., 521(1):137-144, 2020. Takino T, Suzuki T and Seiki M. Isolation of Highly Migratory and Invasive Cells in Three-Dimensional Gels. Curr Protoc Cell Biol., 6(1):e103, 2020. Fukuda K, Takeuchi S, Arai S, Katayama R, Nanjo S, Tanimoto A, Nishiyama A, Nakagawa T, Taniguchi H, Suzuki T, Yamada T, Nishihara H, Ninomiya H, Ishikawa Y, Baba S, Takeuchi K, Horiike A, Yanagitani N, Nishio M, Yano S. Epithelial-to-Mesenchymal Transition Is a Mechanism of ALK Inhibitor Resistance in Lung Cancer Independent of ALK Mutation Status. Cancer Res. 2019 Apr 1;79(7):1658-1670.  Terashima M, Ishimura A, Wanna-Udom S, Suzuki T. MEG8 long noncoding RNA contributes to epigenetic progression of the epithelial-mesenchymal transition of lung and pancreatic cancer cells. J Biol Chem. 2018 Nov 23;293(47):18016-18030.  Terashima M, Ishimura A, Wanna-Udom S, Suzuki T. Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1407-1413.  Terashima M, Tange S, Ishimura A, Suzuki T. MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines. J Biol Chem. 2017 Jan 6;292(1):82-99. Oktyabri D, Ishimura A, Tange S, Terashima M, Suzuki T. DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines. Biochimie. 2016 Apr;123:20-31. Ishimura A, Terashima M, Tange S, Suzuki T. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. Cell Tissue Res. 2016 Mar;363(3):723-33.  Tange S, Oktyabri D, Terashima M, Ishimura A, Suzuki T. JARID2 Is Involved in Transforming Growth Factor-Beta-Induced Epithelial-Mesenchymal Transition of Lung and Colon Cancer Cell Lines. PLoS One. 2014 Dec 26;9(12):e115684. Oktyabri D, Tange S, Terashima M, Ishimura A, Suzuki T. EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-β. Biochem Biophys Res Commun. 2014 Oct 10;453(1):124-30. Enkhbaatar Z, Terashima M, Oktyabri D, Tange S, Ishimura A, Yano S, Suzuki T. KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family Cell Cycle. 2013 Jun 6;12(13) Suzuki T, Terashima M, Tange S, Ishimura A. Roles of histone methyl-modifying enzymes in development and progression of cancer. Cancer Sci. 2013 Apr 8. Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T and Suzuki T. Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development. 2012 Feb;139(4):749-59. Yoshida M, Ishimura A, Terashima M, Enkhbaatar Z, Nozaki N, Satou K, Suzuki T.   PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells.  Biochem J., 437, 555-564, 2011. Terashima M,  Ishimura A, Yoshida Y, Suzuki Y, Sugano S and Suzuki T.  The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase. Biochem. Biophys. Res. Commun. 399(2), 238-244, 2010. Ishimura A, Terashima M, Kimura H, Akagi K, Suzuki Y, Sugano S and Suzuki T.   Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene. Biochem. Biophys. Res. Commun. 389(2), 366-371, 2009. Minehata K, Kawahara A, Suzuki T. Meis1 oncogene regulates the development of endothelial cells in zebrafish. Biochem. Biophys. Res. Commun. 374, 647-652, 2008. Ishimura A, Chida S, Osada S. Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling Nodal signaling in a node-independent manner. Dev. Dyn. 237, 3565-3576, 2008. Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG.   Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J. 25(14):3422-31, 2006. Shin MS, Fredrickson TN, Hartley JW, Suzuki T, Akagi K, Morse HC 3rd.  High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas.  Cancer Res. 64(13):4419-27, 2004. Warming S, Suzuki T, Yamaguchi TP, Jenkins NA, Copeland NG.   Early B-cell factor-associated zinc-finger gene is a frequent target of retroviral integration in murine B-cell lymphomas.  Oncogene  23(15):2727-31, 2004. Akagi K, Suzuki T, Stephens RM, Jenkins NA, Copeland NG.     RTCGD: retroviral tagged cancer gene database. Nucleic Acids Res. 32:D523-7, 2004. Kelly JA, Spolski R, Kovanen PE, Suzuki T, Bollenbacher J, Pise-Masison CA, Radonovich MF, Lee S, Jenkins NA, Copeland NG, Morse HC 3rd, Leonard WJ.    Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.  J Exp Med. 198(1):79-89, 2003. Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis G, Jenkins NA, Copeland NG.   Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related kruppel-like zinc finger protein.  Blood. 101(5):1934-40, 2003. Hiraiwa N, Yabuta T, Yoritomi K, Hiraiwa M, Tanaka Y, Zuzuki T, Yoshida M, Kannagi R. Transactivation of the Fucosyltransferase Vll gene by human T-cell leukemia virus type l Tax through avariant cAMP-responsive element. Blood. 101(9):3615-21,2003. Kim R, Trubetskoy A, Suzuki T, Jenkins NA, Copeland NG, Lenz J.    Genome-based identification of cancer genes by proviral tagging in mouse retrovirus induced T-cell lymphoma.  J Virol. 77(3):2056-62, 2003. Shen H, Suzuki T, Munroe DJ, Stewart C, Rasmussen L, Gilbert DJ, Jenkins NA, Copeland NG.   Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based, mapping and bacterial artificial chromosome hybridization.   J Virol. 77(2):1584-8, 2003. Suzuki T, Shen H, Akagi K, Morse HC, Malley JD, Naiman DQ, Jenkins NA, Copeland NG.     New genes involved in cancer identified by retroviral tagging.    Nature Genet. 32(1):166-74, 2002.