Suzuki T, Uchida-Toita M, Andoh T, Yoshida M.  HTLV-1 Tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity.  Virology  270: 291-298, 2000. Suzuki T, Ohsugi Y, Uchida-Toita M, Akiyama T, Yoshida M.  HTLV-1 Tax oncoprotein binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control. Oncogene 18: 5967-5972, 1999. Suzuki T, Narita T, Uchida-Toita M, Yoshida M.    Down-regulation of INK4 family of cyclin-dependent kinase inhibitors by Tax protein of HTLV-1 through two distinct mechanisms.   Virology 259: 384-391, 1999. Suzuki T, Uchida-Toita M, Yoshida M.    Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site. Oncogene 18: 4137-4143, 1999. Miyake H, Suzuki T, Hirai H, Yoshida M.  Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequen cy of the cellular genome. Virology 253: 155-161, 1999. Suzuki T, Kitao S, Matsushime H, Yoshida M.  HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16ink4a and counteracts its inhibitory activity towards CDK4.  EMBO J. 15: 1607-1614, 1996. Suzuki T, Hirai H, Murakami T, Yoshida M.    Tax protein of HTLV-1 destabilizes the complexes of NF-kB and IkB-a and induces nuclear translocation of NF-kB for transcriptional activation. Oncogene 10: 1199-1207, 1995. Murakami T, Hirai H, Suzuki T, Fujisawa J, Yoshida M.  HTLV-1 Tax enhances NF-kB2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100.   Virology 206: 1066-1074, 1995. Suzuki T, Hirai H, Yoshida M.  Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kB p65 and c-Rel proteins bound to the NF-kB binding site and activates transcription.  Oncogene 9: 3099-3105, 1994. Hirai H, Suzuki T, Fujisawa J, Inoue J, Yoshida M.  Tax protein of human T-cell leukemia virus type 1 (HTLV-1) binds to the ankyrin motif of I-kB and induces nuclear translocation of NF-kB proteins for transcriptional activation. Proc. Natl. Acad. Sci. USA 91: 3584-3588, 1994. Watanabe M, Muramatsu M, Hirai H, Suzuki T, Fujisawa J, Yoshida M, Arai K, Arai N.   HTLV-1 encoded Tax in association with NF-kB precursor p105 enhances nuclear localization of NF-kB p50 and p65 in transfected cells.   Oncogene 8: 2949-2958, 1993. Suzuki T, Hirai H, Fujisawa J, Fujita T, Yoshida M.  A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kB p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kB site and CArG box.   Oncogene 8: 2391-2397, 1993. Suzuki T, Fujisawa J, Toita M, Yoshida M.   A trans-activator Tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1.   Proc. Natl. Acad. Sci. USA 90: 610-614, 1993. Back