Cancer Research Institute of Kanazawa University

　The tumor microenvironment refers to the intricate microenvironment formed by a diverse array of cells, including cancer cells, immune cells, vascular cells, and fibroblasts. Recent studies have elucidated the critical role of the TME in influencing numerous processes involved in tumor initiation and progression, leading to its emerging recognition as a viable therapeutic target, particularly in the context of cancer immunotherapy. This unit is dedicated to addressing the challenge of “bone metastasis,” which exerts a profound adverse effect on quality of life (QOL). This unit aims to achieve a comprehensive molecular understanding of the cancer microenvironment that contributes to the development of bone metastases.