Cancer Research Institute of Kanazawa University

　In multicellular organisms, cell death does not simply mean the end, but can serve as a starting point for new signaling networks. Pyroptosis, a form of necrotic programmed cell death, is accompanied by the release of intracellular inflammatory molecules, induces inflammation, and activates the immune system. Inflammatory and immune responses elicited by pyroptosis are thought to have a significant impact on anti-cancer immunity. This unit is focusing on the gasdermin family molecules, which are the executioners of pyroptosis, to elucidate their activation mechanisms and their roles in the tumor microenvironment.

Recent publications
1. Cell Death Dis. 12:404. (2021)
2. Cell Reports. 34:108887. (2021)
3. Int J Mol Sci. 22:426. (2021)
4. Immunology. 161:114-122. (2020)
5. Microbiology and Immunology. 64:252-269. (2020)
6. Microbiology and Immunology. 64(2):143-152. (2020)
7. Mucosal Immunology. 12(5): 1092-1103. (2019)
8. Nature Communications. 10:2091. (2019)