Aims and the Projects
In multicellular organisms, cell death does not simply mean the end, but can serve as a starting point for new signaling networks. Caspase-1 induces necrotic programmed cell death called pyroptosis, which triggers inflammation through the release of intracellular molecules. These inflammatory responses affect the immune system and cancer cells. In this unit, we are investigating the mechanism of caspase-1-induced cell death and its role in the tumor microenvironment.
Morphology and molecular mechanism of caspase-1-induced cell death