Inflammatory responses occur upon tissue injuries, to reduce tissue damage. If inflammatory responses are exaggerated and prolonged as observed in chronic infection with Helicobacter pylorii, tissue injuries continue, leading sometimes to carcinogenesis.
By interacting with tumor cells, stroma cells and leukocytes can produce various bioactive substances including chemokines. The produced molecules can affect tumor progression and metastasis. We are elucidating the interaction between tumor cells and stroma cells and obtained the following results recently.
Roles of chemokines in tumor progression and metastasis processes
Various chemokines contributes to progression and metastasis through the following functions.
a. Regulation of immune cell trafficking
b. Induction of neovascularization
c. Enhancement of tumor cell motility
d. Induction of production of bioactive substances by tumor and stromal cells
Aberrant expression of a serine / threonine kinase, Pim-3 in malignant lesions
Pim-3, aberrantly expressed in various malignant lesions, inactivates a proapoptotic molecule, Bad by phosphorylating its serine residue, and eventually prevent apoptosis of tumor cells.