Organization

Division of Molecular Bioregulation

Laboratory Web site

Staff

MUKAIDA, Naofumi

Professor
MUKAIDA, Naofumi

BABA, Tomohisa

Assistant Professor
BABA, Tomohisa

SASAKI, Souichirou

Assistant Professor
SASAKI, Souichirou

Aims, Ongoing Projects, and Recent Achievements

 Inflammatory responses occur upon tissue injuries, to reduce tissue damage. If inflammatory responses are exaggerated and prolonged as observed in chronic infection with Helicobacter pylorii, tissue injuries continue, leading sometimes to carcinogenesis.
 By interacting with tumor cells, stroma cells and leukocytes can produce various bioactive substances including chemokines. The produced molecules can affect tumor progression and metastasis. We are elucidating the interaction between tumor cells and stroma cells and obtained the following results recently.

  1. By using mice deficient in chemokine-related genes, we are showing that chemokines can contribute to tumor development and progression by exerting various activities.
  2. We revealed that the expression of a serine/threonine kinase, Pim-3, was aberrantly enhanced in malignant lesions of liver and pancreas. Moreover, aberrantly expressed Pim-3 can inactivate a proapoptotic molecule, Bad by phosphorylating its serine residue, and eventually prevent apoptosis of tumor cells. Thus, Pim-3 may be a good molecular target for cancer treatment.

Roles of chemokines in tumor progression and metastasis processes

Roles of chemokines in tumor progression and metastasis processes
Various chemokines contributes to progression and metastasis through the following functions.
a. Regulation of immune cell trafficking
b. Induction of neovascularization
c. Enhancement of tumor cell motility
d. Induction of production of bioactive substances by tumor and stromal cells

Aberrant expression of a serine / threonine kinase, Pim-3 in malignant lesions

Aberrant expression of a serine / threonine kinase, Pim-3 in malignant lesions

Pim-3, aberrantly expressed in various malignant lesions, inactivates a proapoptotic molecule, Bad by phosphorylating its serine residue, and eventually prevent apoptosis of tumor cells.