Organization

Division of Oncology and Molecular Biology

Laboratory Web site

Staff

TAKAHASHI, Chiaki

Professor
TAKAHASHI, Chiaki

SHAMMA AWAD

Assistant Professor
SHAMMA AWAD

Kohno, Susumu

Research Assistant Professor
Kohno, Susumu

Okada, Nobuhiro

Research Assistant Professor
Okada, Nobuhiro

Aims, Ongoing Projects, and Recent Achievements

 We innovate in vivo and in vitro cancer model systems that can be readily analyzed by genetic and molecular biology techniques. This aims to find pathways critical for carcinogenesis, metastasis, drug resistance, and stem cell-like behaviors in cancer cells. Below are ongoing projects in our laboratory.

  1. The RB tumor suppressor gene product has been implicated in control of cell cycle and terminal differentiation. However, we propose pRB plays many more roles during tumor progression beyond such functions.We focus onpRB functions in chromatin instability, DNA damage response, cellular senescence, mevalonate pathway, lipid metabolism, mitochondrial function, chromatin remodeling and stem celllike behaviors in cancer cells.
  2. Analysis of oncogenic signals that induce malignant behaviors in cancer cells through metabolic reprogramming.
  3. Development of in vivo & in vitro cancer stem cell models in an aim to develop novel drugs or chemicals that specifically target hypothetical cancer stem cells.

Fig.1

Fig.1

Cellular signals merged on the modulation of pRB functions, and effectors of pRB. This at least partially explains multifaceted functions of pRB.

Fig.2

Fig.2

Stem cell-like cells appeared in cancers induced by the combinational suppression of tumor suppressor genes including Rb.