Collaborative usage/research locations

2020 Call for Applications for Collaborative Research Projects at Kanazawa University Cancer Research Institute

 Japan is confronted with a rapidly aging society where cancer causes one in three deaths. While significant progress in cancer treatment has been made over the past several decades, curative treatments remains elusive for many types of cancers due to persistent problems, such as tumor heterogeneity and drug resistance. Understandably, the society continues to place high hopes and expectations on cancer research. To meet this demand and the stern scientific challenge posed by this disease, the Kanazawa University Cancer Research Institute (KU-CRI) has assumed a central role in the field of Cancer Metastasis and Drug Resistance. To this end, the Institute strives to deepen our research by actively promoting collaborative research with researches nationwide. By leveraging our core expertise in cancer stem cells and the tumor microenvironment, we aim to uncover the underlying causes of carcinogenesis, cancer metastasis and resistance, as well as collaborative research projects related to molecular targeted treatment. In support of this high aspiration, the MEXT has re-commissioned the KU-CRI as a “leading collaborative center for cancer metastasis and drug resistance research” from 2016 for a duration of six years. To fulfil this task, the Institute hereby calls for application for research proposal to be conducted in collaboration with the faculties of KU-CRI, to utilize the biomedical resources and state-of-the-art equipment available at our Institute. In FY2020, of domestic collaborative research project, We plan to actively support Young Researchers Incentive Projects and Female Researcher Projects.

Young researcher incentive research projects
A special allocation will be made to (~30) young researchers to conduct collaborative research projects with KU-CRI faculties, as an initiative to nurture and support young researchers engaged in cancer research. A young researcher is classified as aged 39 or younger as of 1 April 2020. Young researcher incentive projects, in general, will be supported more generously than general research projects. Applications are cordially welcomed.

Interdisciplinary research projects
Since FY2017, Kanazawa University has been engaged in an interdisciplinary research initiative called the World Premier International Research Center Initiative (WPI), in which the KU-CRI has also participated. This initiative intends to study and elucidate the molecular and cellular dynamics involved in the malignant transformation of cancer, using the world’s most advanced bio scanning probe microscopy (Bio-SPM) technology and supermolecular chemical technology. In furtherance of this interdisciplinary research initiative, the KU-CRI invites applications for collaborative research projects related to Bio-SPM. For details, please visit the website for applying for Bio-SPM technology collaborative research projects.

No Item Domestic collaborative research project (CRP) International CRP Interdisciplinary CRP
1 Eligible applicant The faculties affiliated with colleges, universities or public research institutions
2 Research period April 1, 2020 – March 31, 2021    
3 Application procedure

i. Confirm details of your CRP in advance with the Institute’s teaching staff by referring to the List of Applicable Research Topics.
ii. Prepare application documents (an application for a domestic collaborative research project and a written consent).
 Forms of application documents can be downloaded from:
 - Application form
 - Consent form
iii. Submit application documents.
– The application for a domestic collaborative research project should be sent via postal or electronic mail to the addresses specified in Section 5. It is not necessary to authenticate the MS Word file with a personal seal when submitting via email.
– All support letters should be authenticated with the official seal of the Head of an affiliated institution. A hard copy should be sent via postal mail to the address specified in Section 5.

Applications should be submitted jointly with the relevant teaching staff of KU-CRI.
Application form
i. Cancer research topics that are of exceptional calibre and interdisciplinary

ii. Application procedure: refer to the website for applying for Bio-SPM technology CRPs
4 Application deadline No later than Friday, 28 February 2020 Any time
5 Address and contact The KU-CRI Office for Joint Usage / Research Center, Kanazawa University Kakuma-machi, Kanazawa 920-1192, Japan

 TEL: +81-76-264-6702
6 Selection Each application will be evaluated by an expert committee that include external cancer researchers
7 Notification i. Applicants will be notified of the outcome by Wednesday, 1 April 2020 (subject to change)
ii. Successful applicants will be appointed “Collaborative Researchers of Kanazawa University Cancer Research Institute.”
Any time Any time
8 Number of projects to be accepted

Approx. 60 projects(Of these, Approx. 30 Young researcher incentive research projects)

Approx. 10 projects Approx. 5 projects
9 Core expenses Expenses incurred in CRPs (supplies and travel expenses) are covered by the Institute within the budget.
Note: The amounts of travel allowances are determined in accordance with the Kanazawa University Personnel Travel Expense Regulations.
Travel, accommodation and research costs incurred in collaborative research conducted during visits to the Institute for several days. Travel and accommodation expenses
10 Maximum budget 400,000 yen (300,000 yen for applications for extension) 300,000 yen 200,000 yen
11 Submission of report Deadline no later than Friday, 23 April 2021.
i. Use the designated form provided;
ii. Instructions and other details for the completion of the report will be provided at a later date;
iii. Reports will be published on the Institute’s website, etc.
See the Bio-SPM technology CRPs website for details on submission form, deadlines and other information.
12 Other requirements i. Scientific publications containing data generated from a CRP funded by this program will include in the Acknowledgment with the following sentence: “This work was partly supported by the Extramural Collaborative Research Grant of Cancer Research Institute, Kanazawa University.” or “The research resources (facility) and technical advicces were kindly provided by the Joint Usage / Research Program of Cancer Research Institute, Kanazawa University.” and so on. A copy of the published manuscript will be submitted to the address provided in Section 5.
ii. A project by the same Principle Investigator may continue for a maximum of three years, in principle. However, this does not apply to a project whose continuation is expected to produce major achievements.
iii. The handling of intellectual property rights is subject to the Kanazawa University Collaborative Research Handling Regulations.
iv. The results of each CRP must be reported through oral or poster presentations, and reported at symposia and results briefing sessions organized by the KU-CRI.
No Item Domestic collaborative research project (CRP) International CRP Interdisciplinary CRP
13 Facilities and equipment
available at the Institute
(1) Resources and facilities available for collaborative research
i. Human Cancer Tissue Bank
 a. Frozen tissues of respiratory and gastrointestinal cancers
 b. Historical cancer tissue samples collected at the University Hospital
ii. Mouse Carcinogenesis Model Tissue Bank
 a. Gastric cancer, colorectal cancer, brain tumor, leukemia
iii. Human Cancer Cell Line Bank
 See the Institute’s website for the procedure for using the banks and related details.
(Mouse carcinogenesis tissues)
(Human cancer tissues and cell lines)
iv. Medicine Libraries
 See the Institute’s website for the types of and procedure for using medicine
v. Other research resources and instruments available for collaborative usage/research
  (expression vectors, antibodies, tissues, cells, modified mice, animal models, etc.)
 For details, see the Institute’s website:
vi. Preclinical Research Facilities (SPF mouse breeding facilities with diagnostic imaging equipment)
vii. Clinical trial facilities (ward facilities available for phase I/II clinical trials)
(2) Central Research Laboratory
Support for using common instruments, such as cell sorter, confocal laser microscope, laser microdissection microscopy system, time lapse fluorescent microscope, pathological tissue sample preparation system
In addition to those listed in the left column, the following Bio-SMP equipment at Kanagawa University NanoLSI:
i. Super-resolution AFM (FM-AFM and 3D-AFM)
ii. High-speed AFM
iii. Scanning ion-conductance microscope (SICM)

List of Applicable Research Topics

No. Name Applicable research topic
Research field
1 Prof. Atsushi Hirao
Division of Molecular Genetics
Clarification of stem cell characteristic control mechanism and investigation of cancer therapy target molecules Interdisciplinary CRPs related to cancer research
2 Prof. Masanobu Oshima
Division of Genetics
Research into occurrence and malignancy mechanism of stomach
3 Prof. Chiaki Takahashi
Division of Oncology and Molecular Biology
Investigation of metabolic mechanism of undifferentiated cancer cells
4 Prof. Naofumi Mukaida
Division of Molecular Bioregulation
Clarification of cancer microenvironment regulatory mechanisms by chemokines and inflammatory cytokines
5 Prof. Takashi Suda
Division of Immunology and Molecular Biology
Research of molecular mechanism of programmed cell death and roles in relation to cancer symptoms
6 Prof. Kunio Matsumoto
Division of Tumor Dynamics and Regulation
Cancer metastasis/drug resistance/tissue regeneration mechanism and drug discovery research centered on HGF-MET system
7 Prof. Noriko Gotoh
Division of Cancer Cell Biology
Analysis of molecular mechanism of cancer malignancy using cancer stem cell culture system of solid cancer
8 Prof. Katsuji Yoshioka
Division of Molecular Cell Signaling
Research into chromosomal instability and cancer cell signaling
9 Prof. Toshinari Minamoto
Division of Translational and Clinical Oncology
Diagnosis and R&D of treatment methods based on molecular pathogenesis and metabolic characteristics of digestive organs/intractable cancer
10 Prof. Takeshi Suzuki
Division of Functional Genomics
Research into epigenetic control of cancer malignancy
11 Prof. Seiji Yano
Division of Medical Oncology
Development of new lung cancer treatments
12 Assoc.Prof. Eishu Hirata
Division of Tumor Cell Biology and Bioimaging
Development of a novel treatment strategy targeting tumor microenvironment

Other matters

“For the objectives, research topics, recent major achievements, etc. in each research field, see below: