Japan is confronted with a rapidly aging society where cancer causes one in three deaths. While significant progress in cancer treatment has been made over the past several decades, curative treatments remains elusive for many types of cancers due to persistent problems, such as tumor heterogeneity and drug resistance. Understandably, the society continues to place high hopes and expectations on cancer research. To meet this demand and the stern scientific challenge posed by this disease, the Kanazawa University Cancer Research Institute (KU-CRI) has assumed a central role in the field of Cancer Metastasis and Drug Resistance. To this end, the Institute strives to deepen our research by actively promoting collaborative research with researches nationwide. By leveraging our core expertise in cancer stem cells and the tumor microenvironment, we aim to uncover the underlying causes of carcinogenesis, cancer metastasis and resistance, as well as collaborative research projects related to molecular targeted treatment. In support of this high aspiration, the MEXT has re-commissioned the KU-CRI as a “leading collaborative center for cancer metastasis and drug resistance research” from 2016 for a duration of six years. To fulfil this task, the Institute hereby calls for application for research proposal to be conducted in collaboration with the faculties of KU-CRI, to utilize the biomedical resources and state-of-the-art equipment available at our Institute. In addition, in FY2019, applications for Young Researchers Incentive Projects and Interdisciplinary Research Projects are also invited.
Young researcher incentive research projects
Starting from FY2019, a special allocation will be made to (~10) young researchers to conduct collaborative research projects with KU-CRI faculties, as an initiative to nurture and support young researchers engaged in cancer research. A young researcher is classified as aged 39 or younger as of 1 April 2019. Young researcher incentive projects, in general, will be supported more generously than general research projects. Applications are cordially welcomed.
Interdisciplinary research projects
Since FY2017, Kanazawa University has been engaged in an interdisciplinary research initiative called the World Premier International Research Center Initiative (WPI), in which the KU-CRI has also participated. This initiative intends to study and elucidate the molecular and cellular dynamics involved in the malignant transformation of cancer, using the world’s most advanced bio scanning probe microscopy (Bio-SPM) technology and supermolecular chemical technology. In furtherance of this interdisciplinary research initiative, the KU-CRI invites applications for collaborative research projects related to Bio-SPM. For details, please visit the website for applying for Bio-SPM technology collaborative research projects .
|No||Item||Domestic collaborative research project (CRP)||International CRP||Interdisciplinary CRP|
|1||Eligible applicant||The faculties affiliated with colleges, universities or public research institutions|
|2||Research period||April 1, 2019 – March 31, 2020|
i. Confirm details of your CRP in advance with the Institute’s teaching staff by referring to the List of Applicable Research Topics.
|Applications should be submitted jointly with the relevant teaching staff of KU-CRI.
– Application form
|i. Cancer research topics that are of exceptional calibre and interdisciplinary
ii. Application procedure: refer to the website for applying for Bio-SPM technology CRPs
|4||Application deadline||No later than Monday, 4 March 2019||Any time|
|5||Address and contact||The KU-CRI Office for Joint Usage / Research Center, Kanazawa University Kakuma-machi, Kanazawa 920-1192, Japan
|6||Selection||Each application will be evaluated by an expert committee that include external cancer researchers|
|7||Notification||i. Applicants will be notified of the outcome by Monday, 1 April 2019 (subject to change)
ii. Successful applicants will be appointed “Collaborative Researchers of Kanazawa University Cancer Research Institute.”
|Any time||Any time|
|8||Number of projects to be accepted||Approx. 60 projects||–||Approx. 5 projects|
|9||Core expenses||Expenses incurred in CRPs (supplies and travel expenses) are covered by the Institute within the budget.
Note: The amounts of travel allowances are determined in accordance with the Kanazawa University Personnel Travel Expense Regulations.
|Travel, accommodation and research costs incurred in collaborative research conducted during visits to the Institute for several days.||Travel and accommodation expenses|
|10||Maximum budget||500,000 yen (400,000 yen for applications for extension)||300,000 yen||200,000 yen|
|11||Submission of Report||Deadline No later than Friday, 24 April 2020.
i. Use the designated form provided;
ii. Instructions and other details for the completion of the Repor will be provided at a later date;
iii. Reports will be published on the Institute’s website, etc.
|–||See the Bio-SPM technology CRPs website for details on submission form, deadlines and other information.|
|12||Other requirements||i. Scientific publications containing data generated from a CRP funded by this program will include in the Acknowledgment with the following sentence: “This work was partly supported by the Extramural Collaborative Research Grant of Cancer Research Institute, Kanazawa University.” A copy of the published manuscript will be submitted to the address provided in Section 5.|
|ii. A project by the same Principle Investigator may continue for a maximum of three years, in principle. However, this does not apply to a project whose continuation is expected to produce major achievements.|
|iii. The handling of intellectual property rights is subject to the Kanazawa University Collaborative Research Handling Regulations.|
|iv. The results of each CRP must be reported through oral or poster presentations, and reported at symposia and results briefing sessions organized by the KU-CRI.||–||–|
List of Applicable Research Topics
|No.||Name||Applicable research topic|
|1||Prof. Atsushi Hirao
Division of Molecular Genetics
|Clarification of stem cell characteristic control mechanism and investigation of cancer therapy target molecules||Interdisciplinary CRPs related to cancer research|
|2||Prof. Masanobu Oshima
Division of Genetics
|Research into occurrence and malignancy mechanism of stomach|
|3||Prof. Chiaki Takahashi
Division of Oncology and Molecular Biology
|Investigation of metabolic foundation of undifferentiated cancer cells|
|4||Prof. Naofumi Mukaida
Division of Molecular Bioregulation
|Clarification of cancer microenvironment regulatory mechanisms by chemokines and inflammatory cytokines|
|5||Prof. Takashi Suda
Division of Immunology and Molecular Biology
|Research of molecular mechanism of programmed cell death and roles in relation to cancer symptoms|
|6||Prof. Kunio Matsumoto
Division of Tumor Dynamics and Regulation
|Cancer metastasis/drug resistance/tissue regeneration mechanism and drug discovery research centered on HGF-MET system|
|7||Prof. Noriko Gotoh
Division of Cancer Cell Biology
|Analysis of molecular mechanism of cancer malignancy using cancer stem cell culture system of solid cancer|
|8||Prof. Katsuji Yoshioka
Division of Molecular Cell Signaling
|Research into cancer cell signaling|
|9||Prof. Toshinari Minamoto
Division of Translational and Clinical Oncology
|Diagnosis and R&D of treatment methods based on molecular pathogenesis and metabolic characteristics of digestive organs/intractable cancer|
|10||Prof. Takeshi Suzuki
Division of Functional Genomics
|Research into epigenetic control of cancer malignancy|
|11||Prof. Seiji Yano
Division of Medical Oncology
|Development of new lung cancer treatments|
|12||Assoc.Prof. Eishu Hirata
Division of Tumor Cell Biology and Bioimaging
|Development of a novel treatment strategy targeting tumor microenvironment|
“For the objectives, research topics, recent major achievements, etc. in each research field, see below: