MEXT Promotion of Development of a Joint Usage/Research System Project:
Coalition of Universities for Research Excellence Program (CURE)
Establishing a collaborative intelligence platform towards extending healthy life expectancy
Adopted Joint Research Projects
FY2024
| No. | Type | Institute | Affiliation | Title | Principal Investigator | Research Title |
|---|---|---|---|---|---|---|
| 06-01 | Top-down | Kanazawa University | Cancer Research Institute | Professor | HIRAO Atsushi | Deciphering metabolic and immunoregulatory mechanisms of aging: towards intervention methodologies |
| 06-02 | Bottom-up | Kanazawa University | Cancer Research Institute | Professor | OKAMOTO Kazuo | Elucidation of the mechanism underlying cancer and inflammation-induced disruption of bone marrow environmental network for bone health science |
| 06-03 | Bottom-up | Kanazawa University | Cancer Research Institute | Associate Professor | OSHIMA Hiroko | Interactions between the cancer microenvironment and tumor cells using devices |
| 06-04 | Bottom-up | Kanazawa University | Cancer Research Institute | Assistant Professor | ISHIBASHI Kojiro | Glial mechanobiology links brain metastasis and aging |
| 06-05 | Bottom-up | Kanazawa University | Cancer Research Institute | Assistant Professor | HONGU Tsunaki | Comprehensive functional analysis of mitochondrial one-carbon metabolism in aged/obese tumor microenvironment |
| 06-06 | Bottom-up | Kanazawa University | Cancer Research Institute | Assistant Professor | KOHNO Susumu | Targeting metabolic vulnerability in advanced prostate cancer |
| 06-07 | Top-down | Tohoku University | Institute of Development, Aging and Cancer | Associate Professor | KAWAOKA Shinpei | Roles of nicotinamide-N-methyltransferase in metabolic disorders including cancer cachexia |
| 06-08 | Top-down | Tohoku University | Institute of Development, Aging and Cancer | Assistant Professor | OKAZAKI Keito | Multi-Organ Network analysis in pulmonary fibrosis and search for therapeutic factor |
| 06-09 | Top-down | Tohoku University | Institute of Development, Aging and Cancer | Professor | CHIBA Natsuko | Development of a method to measure homologous recombination activity of breast cancer organoids |
| 06-10 | Bottom-up | Tohoku University | Institute of Development, Aging and Cancer | Assistant Professor | IEMURA Kenji | Analysis of the effect of KIF18A inhibitors on the growth of breast cancer organoids |
| 06-11 | Bottom-up | Tohoku University | Institute of Development, Aging and Cancer | Assistant Professor | WATANABE Kazuki | Elucidation of the influence of NKG2D on the pathophysiology of periodontal disease and its mechanism |
| 06-12 | Top-down | Tohoku University | Institute of Development, Aging and Cancer | Professor | WEI Fanyan | Exploring the molecular mechanism of epitranscriptome ageing |
| 06-13 | Bottom-up | Tohoku University | Institute of Development, Aging and Cancer | Assistant Professor | SUZUKI Takaya | Investigation of the aging hallmarks using hyperacute neurogenic pulmonary edema model in aged mice |
| 06-14 | Inter-disciplinary | Tohoku University | Institute of Development, Aging and Cancer | Assistant Professor | SAKAKI Kohei | Cognitive neuroscientific study of creative problem-solving ability in elderly people |
| 06-15 | Inter-disciplinary | Tohoku University | Institute of Development, Aging and Cancer | Assistant Professor | TAKEMOTO Ayumi | Neural mechanism of social isolation in older adults using virtual avatar communication |
| 06-16 | Inter-disciplinary | Tohoku University | Institute of Development, Aging and Cancer | Lecturer | OKAMOTO Yuko | Effects of optimism induction on experimental pain and brain activities |
| 06-17 | Top-down | Osaka University | Research Institute for Microbial Diseases | Professor | YAMASAKI Sho | Identification of lipid-specific T cell subsets to counteract host immune evasion by virus |
| 06-18 | Top-down | Osaka University | Research Institute for Microbial Diseases | Professor | TAKAKURA Nobuyuki | Development of therapy for cancer cachexia |
| 06-19 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Professor | ISHITANI Tohru | Constructing genome information of new aging model animals and exploring aging regulating factors |
| 06-20 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Professor | HARA Eiji | The influence of the oral microflora on oral cancer microenvironment |
| 06-21 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Professor | IKAWA Masahito | Analysis of fertility decline in the middle reproductive age of females in mice |
| 06-22 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Professor | KOTANI Ai | Identification of intracellular molecular mechanisms regulating transferrin dependence in aggressive NK cell leukemia |
| 06-23 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Assistant Professor | MURAMATSU Fumitaka | Ceruloplasmin from tumor blood vessels promotes drug resistance in glioblastoma |
| 06-24 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Graduate Student | MATSUMOTO Kinnosuke | Elucidation of the interaction between high endothelial venules and immunotherapy in non-small cell lung caner |
| 06-25 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Specially Assistant Professor | KAMAKURA Takefumi | Spatial transcriptomics of FADS6 gene in human pancreas tissue with Xenium |
| 06-26 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Associate Professor | KAWAMOTO Shimpei | Elucidation of the mechanism of B cell senescence in human ileum |
| 06-27 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Graduate Student | NODA Yoshimi | Functional analysis of endothelial stem cells in idiopathic pulmonary fibrosis using Xenium in situ |
| 06-28 | Top-down | Keio University | Institute for Advanced Biosciences | Project Associate Professor | SAITO Yasuhiko | Comprehensive analysis of intracellular RNA metabolism in cancer cells |
| 06-29 | Top-down | Keio University | Institute for Advanced Biosciences | Professor | SOGA Tomoyoshi | Elucidation of human acute myeloid leukemia-specific ammonia detoxification pathway |
| 06-30 | Inter-disciplinary | Keio University | Institute for Advanced Biosciences | Professor | AKIYAMA Miki | Research on methods for disseminating research results related to healthy lifespan science to the general public |
| 06-31 | Bottom-up | Keio University | Institute for Advanced Biosciences | Researcher | HAYASAKA Ryosuke | Metabolomic analysis of extracellular vesicles released by cellular senescence as senescence-associated secretory phenotype (SASP) |
| 06-32 | Bottom-up | Keio University | Institute for Advanced Biosciences | Project Research Associate | YANG Jiayue | Mechanism elucidation of colitis attenuation by an intestinal mucosa-associate bacterium |
| 06-33 | Bottom-up | Keio University | Institute for Advanced Biosciences / Faculty of Environment and Information Studies | JSPS Restart Postdoctoral Fellowship | ISHII Chiharu | Investigation and mechanistic elucidation of the lifespan-extending effects of metabolites derived from the intestinal microbiota |
FY2023
| No. | Type | Institute | Affiliation | Title | Principal Investigator | Research Title |
|---|---|---|---|---|---|---|
| 05-01 | Top-down | Kanazawa University | Cancer Research Institute | Professor | HIRAO Atsushi | Elucidation of metabolic and immunoregulatory mechanisms of aging |
| 05-02 | Top-down | Kanazawa University | Cancer Research Institute | Assistant Professor | KOHNO Susumu | Study of metabolic deficiency in prostate cancer |
| 05-03 | Bottom-up | Kanazawa University | Cancer Research Institute | Associate Professor | BABA Tomohisa | Therapeutic strategy targeting cancer-associated fibroblasts with a senescent phenotype in bone metastasis of breast cancer |
| 05-04 | Bottom-up | Kanazawa University | Cancer Research Institute | Associate Professor | OSHIMA Hiroko | Interactions between the cancer microenvironment and tumor cells using devices |
| 05-05 | Bottom-up | Kanazawa University | Cancer Research Institute | Assistant Professor | HONGU Tsunaki | Comprehensive functional analysis of mitochondrial one-carbon metabolism in tumor microenvironment of aged/obese mice |
| 05-06 | Bottom-up | Kanazawa University | Cancer Research Institute | Assistant Professor | ISHIBASHI Kojiro | Glial mechanobiology links brain metastasis and aging |
| 05-07 | Bottom-up | Kanazawa University | Cancer Research Institute | Associate Professor | MURAKAMI Kazuhiro | Development of β-hCG inhibitors and its validation using microfluidic organoids culture device |
| 05-08 | Inter-disciplinary | Kanazawa University | Institute of Human and Social Sciences | Associate Professor | IKKATAI Yuko | Psychological factors analysis for improving the attendance rate of endoscopic examination in gastric cancer screening. |
| 05-09 | Top-down | Tohoku University | Institute of Development, Aging, and Cancer | Associate Professor | KAWAOKA Shinpei | Roles of NNMT in cancer cachexia and related metabolic disorders |
| 05-10 | Top-down | Tohoku University | Institute of Development, Aging, and Cancer | Assistant Professor | IEMURA Kenji | Analysis of the effect of KIF18A inhibitors on the growth of breast cancer organoids |
| 05-11 | Top-down | Tohoku University | Institute of Development, Aging, and Cancer | Professor | CHIBA Natsuko | Development of a method to measure homologous recombination activity of breast cancer organoids |
| 05-12 | Top-down | Tohoku University | Institute of Development, Aging, and Cancer | Assistant Professor | MURAKAMI Shohei | Physiological function of CARS1-mediated supersulfide production in skeletal muscle |
| 05-13 | Bottom-up | Tohoku University | Institute of Development, Aging, and Cancer | Assistant Professor | SUZUKI Takaya | Investigation of the aging hallmarks using hyperacute neurogenic pulmonary edema model in aged mice. |
| 05-14 | Bottom-up | Tohoku University | Institute of Development, Aging, and Cancer | Assistant Professor | TANABE Azumi | Investigation of neural basis and age-related changes for kinesthetic working memory |
| 05-15 | Bottom-up | Tohoku University | Institute of Development, Aging, and Cancer | Assistant Professor | RYOKE Rie | Age-Dependent Influences on Brain Waste Processing Mechanisms: A Small Animal MRI Study |
| 05-16 | Bottom-up | Tohoku University | Institute of Development, Aging, and Cancer | Assistant Professor | TAKEMOTO Ayumi | Cognitive Neuroscience for Healthy Life Span: Establishment of an Interdisciplinary Collaborative Research Platform |
| 05-17 | Top-down | Osaka University | Research Institute for Microbial Diseases | Professor | YAMASAKI Sho | Identification of lipid-specific T cell subsets to counteract host immune evasion by virus |
| 05-18 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Professor | ISHITANI Tohru | Constructing genome information of new aging model animals and exploring aging regulating factors |
| 05-19 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Professor | HARA Eiji | The influence of the oral microflora on oral cancer microenvironment |
| 05-20 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Professor | IKAWA Masahito | Analysis of fertility decline in the middle reproductive age of females in mice |
| 05-21 | Bottom-up | Osaka University | Research Institute for Microbial Diseases | Assistant Professor | MURAMATSU Fumitaka | Ceruloplasmin from tumor blood vessels promotes drug resistance in glioblastoma |
| 05-22 | Top-down | Keio University | Institute for Advanced Biosciences | Professor | SOGA Tomoyoshi | Elucidation of metabolic alterations underlying chronic stress-induced brain pathology |
| 05-23 | Bottom-up | Keio University | Institute for Advanced Biosciences | Professor | SOGA Tomoyoshi | Elucidation of human acute myeloid leukemia-specific ammonia-detoxication pathway |
| 05-24 | Bottom-up | Keio University | Institute for Advanced Biosciences | Professor | SOGA Tomoyoshi | Discovery and mechanism of the novel oncometabolites |
| 05-25 | Top-down | Keio University | Institute for Advanced Biosciences | Professor | SOGA Tomoyoshi | Search for small molecule biomarkers of various renal diseases |