MEXT Promotion of Development of a Joint Usage/Research System Project:
Coalition of Universities for Research Excellence Program (CURE)

Establishing a collaborative intelligence platform towards extending healthy life expectancy

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Adopted Joint Research Projects

FY2024

FY2023

No. Type Institute Affiliation Title Principal Investigator Research Title
05-01 Top-down Kanazawa University Cancer Research Institute Professor HIRAO Atsushi Elucidation of metabolic and immunoregulatory mechanisms of aging
05-02 Top-down Kanazawa University Cancer Research Institute Assistant Professor KOHNO Susumu Study of metabolic deficiency in prostate cancer
05-03 Bottom-up Kanazawa University Cancer Research Institute Associate Professor BABA Tomohisa Therapeutic strategy targeting cancer-associated fibroblasts with a senescent phenotype in bone metastasis of breast cancer
05-04 Bottom-up Kanazawa University Cancer Research Institute Associate Professor OSHIMA Hiroko Interactions between the cancer microenvironment and tumor cells using devices
05-05 Bottom-up Kanazawa University Cancer Research Institute Assistant Professor HONGU Tsunaki Comprehensive functional analysis of mitochondrial one-carbon metabolism in tumor microenvironment of aged/obese mice
05-06 Bottom-up Kanazawa University Cancer Research Institute Assistant Professor ISHIBASHI Kojiro Glial mechanobiology links brain metastasis and aging
05-07 Bottom-up Kanazawa University Cancer Research Institute Associate Professor MURAKAMI Kazuhiro Development of β-hCG inhibitors and its validation using microfluidic organoids culture device
05-08 Inter-disciplinary Kanazawa University Institute of Human and Social Sciences Associate Professor IKKATAI Yuko Psychological factors analysis for improving the attendance rate of endoscopic examination in gastric cancer screening.
05-09 Top-down Tohoku University Institute of Development, Aging, and Cancer Associate Professor KAWAOKA Shinpei Roles of NNMT in cancer cachexia and related metabolic disorders
05-10 Top-down Tohoku University Institute of Development, Aging, and Cancer Assistant Professor IEMURA Kenji Analysis of the effect of KIF18A inhibitors on the growth of breast cancer organoids
05-11 Top-down Tohoku University Institute of Development, Aging, and Cancer Professor CHIBA Natsuko Development of a method to measure homologous recombination activity of breast cancer organoids
05-12 Top-down Tohoku University Institute of Development, Aging, and Cancer Assistant Professor MURAKAMI Shohei Physiological function of CARS1-mediated supersulfide production in skeletal muscle
05-13 Bottom-up Tohoku University Institute of Development, Aging, and Cancer Assistant Professor SUZUKI Takaya Investigation of the aging hallmarks using hyperacute neurogenic pulmonary edema model in aged mice.
05-14 Bottom-up Tohoku University Institute of Development, Aging, and Cancer Assistant Professor TANABE Azumi Investigation of neural basis and age-related changes for kinesthetic working memory
05-15 Bottom-up Tohoku University Institute of Development, Aging, and Cancer Assistant Professor RYOKE Rie Age-Dependent Influences on Brain Waste Processing Mechanisms: A Small Animal MRI Study
05-16 Bottom-up Tohoku University Institute of Development, Aging, and Cancer Assistant Professor TAKEMOTO Ayumi Cognitive Neuroscience for Healthy Life Span: Establishment of an Interdisciplinary Collaborative Research Platform
05-17 Top-down Osaka University Research Institute for Microbial Diseases Professor YAMASAKI Sho Identification of lipid-specific T cell subsets to counteract host immune evasion by virus
05-18 Bottom-up Osaka University Research Institute for Microbial Diseases Professor ISHITANI Tohru Constructing genome information of new aging model animals and exploring aging regulating factors
05-19 Bottom-up Osaka University Research Institute for Microbial Diseases Professor HARA Eiji The influence of the oral microflora on oral cancer microenvironment
05-20 Bottom-up Osaka University Research Institute for Microbial Diseases Professor IKAWA Masahito Analysis of fertility decline in the middle reproductive age of females in mice
05-21 Bottom-up Osaka University Research Institute for Microbial Diseases Assistant Professor MURAMATSU Fumitaka Ceruloplasmin from tumor blood vessels promotes drug resistance in glioblastoma
05-22 Top-down Keio University Institute for Advanced Biosciences Professor SOGA Tomoyoshi Elucidation of metabolic alterations underlying chronic stress-induced brain pathology
05-23 Bottom-up Keio University Institute for Advanced Biosciences Professor SOGA Tomoyoshi Elucidation of human acute myeloid leukemia-specific ammonia-detoxication pathway
05-24 Bottom-up Keio University Institute for Advanced Biosciences Professor SOGA Tomoyoshi Discovery and mechanism of the novel oncometabolites
05-25 Top-down Keio University Institute for Advanced Biosciences Professor SOGA Tomoyoshi Search for small molecule biomarkers of various renal diseases